About this Research Topic

Abstract Submission Deadline 02 September 2022
Manuscript Submission Deadline 01 November 2022

Cancer immunometabolism is an emerging field exploring cellular bioenergetic alterations in both tumor and immune cells and their impact on tumor immune surveillance and therapy resistance. Multiple concepts have emerged including metabolic competition over nutrients and the secretion of (toxic) metabolic byproducts by cancer cells. Moreover, cancer cells are capable of utilizing and shaping their surrounding microenvironment to their favor, e.g. by reprogramming stroma cells to produce essential nutrients or by providing metabolically relevant signaling molecules to foster the accumulation of immunosuppressive cells. Most importantly, this crosstalk within the tumor microenvironment is mostly multi-directional and a better understanding of the complex interactions may pave the way to improved and/or novel therapeutic strategies to overcome those obstacles.

Recent advances in the field of cancer immunometabolism have shown that many of the metabolic alterations in malignant cells may lead to so-called metabolic barriers, resulting in an inefficient anti-tumor immune response as well as therapeutic failure. However, the complexity of the metabolic network is still incompletely understood and needs further research in order to improve patient outcomes, especially with regard to personalized medicine.

This Research Topic welcomes Original Research articles, Review articles and Case Reports covering the following topics:
- Identification of metabolic alterations in tumor and immune cells leading to a failure in anti-tumor immune response or therapy resistance
- Multi-directional cross-talk within the tumor microenvironment resulting in a metabolic barrier
- Exploration of the impact of lifestyle (e.g. diets, physical activities etc.) on cellular metabolism and cell functions within the TME
- Strategies for metabolic manipulation to restore immune cell functions and/or therapeutic efficacy

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.

Keywords: Cancer Metabolism, Immunometabolism, Immunotherapy, Cellular Therapy, Metabolic Vulnerability, Metabolic Toxicity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Cancer immunometabolism is an emerging field exploring cellular bioenergetic alterations in both tumor and immune cells and their impact on tumor immune surveillance and therapy resistance. Multiple concepts have emerged including metabolic competition over nutrients and the secretion of (toxic) metabolic byproducts by cancer cells. Moreover, cancer cells are capable of utilizing and shaping their surrounding microenvironment to their favor, e.g. by reprogramming stroma cells to produce essential nutrients or by providing metabolically relevant signaling molecules to foster the accumulation of immunosuppressive cells. Most importantly, this crosstalk within the tumor microenvironment is mostly multi-directional and a better understanding of the complex interactions may pave the way to improved and/or novel therapeutic strategies to overcome those obstacles.

Recent advances in the field of cancer immunometabolism have shown that many of the metabolic alterations in malignant cells may lead to so-called metabolic barriers, resulting in an inefficient anti-tumor immune response as well as therapeutic failure. However, the complexity of the metabolic network is still incompletely understood and needs further research in order to improve patient outcomes, especially with regard to personalized medicine.

This Research Topic welcomes Original Research articles, Review articles and Case Reports covering the following topics:
- Identification of metabolic alterations in tumor and immune cells leading to a failure in anti-tumor immune response or therapy resistance
- Multi-directional cross-talk within the tumor microenvironment resulting in a metabolic barrier
- Exploration of the impact of lifestyle (e.g. diets, physical activities etc.) on cellular metabolism and cell functions within the TME
- Strategies for metabolic manipulation to restore immune cell functions and/or therapeutic efficacy

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.

Keywords: Cancer Metabolism, Immunometabolism, Immunotherapy, Cellular Therapy, Metabolic Vulnerability, Metabolic Toxicity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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