About this Research Topic
Recent advances in the field of cancer immunometabolism have shown that many of the metabolic alterations in malignant cells may lead to so-called metabolic barriers, resulting in an inefficient anti-tumor immune response as well as therapeutic failure. However, the complexity of the metabolic network is still incompletely understood and needs further research in order to improve patient outcomes, especially with regard to personalized medicine.
This Research Topic welcomes Original Research articles, Review articles and Case Reports covering the following topics:
- Identification of metabolic alterations in tumor and immune cells leading to a failure in anti-tumor immune response or therapy resistance
- Multi-directional cross-talk within the tumor microenvironment resulting in a metabolic barrier
- Exploration of the impact of lifestyle (e.g. diets, physical activities etc.) on cellular metabolism and cell functions within the TME
- Strategies for metabolic manipulation to restore immune cell functions and/or therapeutic efficacy
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: Cancer Metabolism, Immunometabolism, Immunotherapy, Cellular Therapy, Metabolic Vulnerability, Metabolic Toxicity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.