Locomotor system is made up of the skeleton, the skeletal muscles, tendons, et al. These parts work together to allow movement. Due to trauma, aging, or chronic disease, the locomotor system can degenerate dramatically or only partially regenerate. Tissue engineering has been widely discussed because biomaterials can replace damaged tissue. However, for degenerative disorders, such as osteoporosis, osteoarthritis, sarcopenia, etc., the tissue is degenerating as a whole, hence the application of tissue engineering is limited, which is desperately needed to find an alternative strategy.
In recent decades, stem cells and biomaterials with drug-loading/controlled-release potential have made progress in treating degenerations of locomotor system. There are increasingly researches with fruitful results on exosomes, liposomes, or mesoporous materials. DNAs, RNAs, and even natural compounds have been proved to be pro-regenerative. Bioinformatic datasets and pharmaceutical tools also allow the discovery of novel agents with pro-regenerative potential for bone and muscle, which enrich the choices for drug loading/delivery.
The aims of this Research Topic are to report the advancement of stem cells, stem cell-related agents, and biomaterials with drug-loading potential against the degeneration of lomocotor system caused by aging, systematic disorders, or trauma et al. In an attempt to treat the disorders of bone, cartilage, and skeletal muscle, it is welcome to discover the novel agents with loading potential via experiments, network pharmacology, or bioinformatics tools. It is also interesting to modify biomaterials to match or adjust the local microenvironment. Both original research articles and review articles are welcomed.
• The application of stem cells and stem cell-derived materials for inhibiting locomotor system degenerations
• The development of biomaterials to load drugs against locomotor system degenerations
• The modification of biomaterials with controlled-release potential for bone/cartilage/skeletal muscle lesions
• The discovery of novel agents/targets against bone/cartilage/skeletal muscle disorders
• The innovative application of already-known agents against locomotor system degenerations
• The design of biomaterials capable of interacting with local micro-environment of bone/cartilage/skeletal muscle
Locomotor system is made up of the skeleton, the skeletal muscles, tendons, et al. These parts work together to allow movement. Due to trauma, aging, or chronic disease, the locomotor system can degenerate dramatically or only partially regenerate. Tissue engineering has been widely discussed because biomaterials can replace damaged tissue. However, for degenerative disorders, such as osteoporosis, osteoarthritis, sarcopenia, etc., the tissue is degenerating as a whole, hence the application of tissue engineering is limited, which is desperately needed to find an alternative strategy.
In recent decades, stem cells and biomaterials with drug-loading/controlled-release potential have made progress in treating degenerations of locomotor system. There are increasingly researches with fruitful results on exosomes, liposomes, or mesoporous materials. DNAs, RNAs, and even natural compounds have been proved to be pro-regenerative. Bioinformatic datasets and pharmaceutical tools also allow the discovery of novel agents with pro-regenerative potential for bone and muscle, which enrich the choices for drug loading/delivery.
The aims of this Research Topic are to report the advancement of stem cells, stem cell-related agents, and biomaterials with drug-loading potential against the degeneration of lomocotor system caused by aging, systematic disorders, or trauma et al. In an attempt to treat the disorders of bone, cartilage, and skeletal muscle, it is welcome to discover the novel agents with loading potential via experiments, network pharmacology, or bioinformatics tools. It is also interesting to modify biomaterials to match or adjust the local microenvironment. Both original research articles and review articles are welcomed.
• The application of stem cells and stem cell-derived materials for inhibiting locomotor system degenerations
• The development of biomaterials to load drugs against locomotor system degenerations
• The modification of biomaterials with controlled-release potential for bone/cartilage/skeletal muscle lesions
• The discovery of novel agents/targets against bone/cartilage/skeletal muscle disorders
• The innovative application of already-known agents against locomotor system degenerations
• The design of biomaterials capable of interacting with local micro-environment of bone/cartilage/skeletal muscle
