During the past decades, DNA dynamic reactions have evolved from simple Boolean gates to functional algorithms at the molecular level with predictable results. Compared with semiconductor microchips which perform tasks on a solid platform, DNA dynamic reactions can functionize seamlessly with biological targets, e.g., other nucleic acids, proteins, small molecules, and even cellular states, in their immediate biological environments. As a result, DNA dynamic reactions can be inserted into natural systems and perform specific functions, such as in situ bioanalysis, smart theranostic, and autonomous bioregulation. The development of controllable computational circuits in vitro and bio-functional reactions for intracellular applications with reduced leakage and less nonspecific response extensively improved the sensitivity and specificity of respective bioanalysis applications, as well as in vivo bioimaging. Besides, DNA nanotechnology provides the precisely controlled assembly of various nanomaterials such as gold nanoparticles, quantum dots, etc. Either physical or chemical properties of these nanostructures could be mediated through the controllable and programmable DNA dynamic reactions. Taking advantage of DNA programmed nanomaterials’ unique features, nowadays, tremendous biomedical applications were developed in disease diagnostics, biomarker analysis, and drug delivery. Thus, the advancements in programmable DNA nanostructures and dynamic reactions are of great importance not only in nanotechnology but also in biomedicine and materials science.
This Research Topic aims at covering important, emerging, and promising research trends focus on the construction and biological applications of programmable DNA dynamic reactions, especially implementations that emphasize the bioanalytical and biomedical potential of DNA dynamic reactions in complex bioenvironments.
We welcome the submission of Original Research, Review, Mini-Review, and Perspective articles on themes that may include, but are not limited to:
• Construction of smart DNA systems for biological and biomedical approaches;
• High specific DNA molecular or nanoprobes for intracellular or in vivo bioimaging;
• Reliable biosensing strategies based on programmable DNA systems;
• Customized bioregulation using DNA dynamic reaction;
• Construct smart biosensors based on DNA system and functional nanostructures;
• DNA dynamic reaction enabled mediation of nanomaterials properties.
During the past decades, DNA dynamic reactions have evolved from simple Boolean gates to functional algorithms at the molecular level with predictable results. Compared with semiconductor microchips which perform tasks on a solid platform, DNA dynamic reactions can functionize seamlessly with biological targets, e.g., other nucleic acids, proteins, small molecules, and even cellular states, in their immediate biological environments. As a result, DNA dynamic reactions can be inserted into natural systems and perform specific functions, such as in situ bioanalysis, smart theranostic, and autonomous bioregulation. The development of controllable computational circuits in vitro and bio-functional reactions for intracellular applications with reduced leakage and less nonspecific response extensively improved the sensitivity and specificity of respective bioanalysis applications, as well as in vivo bioimaging. Besides, DNA nanotechnology provides the precisely controlled assembly of various nanomaterials such as gold nanoparticles, quantum dots, etc. Either physical or chemical properties of these nanostructures could be mediated through the controllable and programmable DNA dynamic reactions. Taking advantage of DNA programmed nanomaterials’ unique features, nowadays, tremendous biomedical applications were developed in disease diagnostics, biomarker analysis, and drug delivery. Thus, the advancements in programmable DNA nanostructures and dynamic reactions are of great importance not only in nanotechnology but also in biomedicine and materials science.
This Research Topic aims at covering important, emerging, and promising research trends focus on the construction and biological applications of programmable DNA dynamic reactions, especially implementations that emphasize the bioanalytical and biomedical potential of DNA dynamic reactions in complex bioenvironments.
We welcome the submission of Original Research, Review, Mini-Review, and Perspective articles on themes that may include, but are not limited to:
• Construction of smart DNA systems for biological and biomedical approaches;
• High specific DNA molecular or nanoprobes for intracellular or in vivo bioimaging;
• Reliable biosensing strategies based on programmable DNA systems;
• Customized bioregulation using DNA dynamic reaction;
• Construct smart biosensors based on DNA system and functional nanostructures;
• DNA dynamic reaction enabled mediation of nanomaterials properties.
