About this Research Topic
In recent years, there have been increasing reports of MDR and XDR A. baumannii infection worldwide. Several known pathogenic factors, including lipopolysaccharide, capsular polysaccharides, protein secretion systems, efflux pumps and biofilm formation, have been reported to be involved in antibiotic resistance, environmental persistence, host-pathogen interactions, and immune evasion. However, the specific mechanism remains unclear.
The exploration of the molecular epidemiology and antibiotic resistance mechanisms of A. baumannii is of great significance for the therapeutic development of A. baumannii infection.
This Research Topic focuses on the molecular epidemiology and antibiotic resistance mechanism of A. baumannii to novel antibacterial drugs, including but not limited to tigecycline, eravacycline, colistin, cefiderocol.
We welcome high-quality contributions, including Original Research and Review, addressing the following topics:
(1)Multicenter molecular epidemiology of A. baumannii to novel antibacterial drugs
(2)Antibiotic resistance mechanism of A. baumannii to novel antibacterial drugs
(3)In vivo evolution of A. baumannii under novel antimicrobial therapy
(4)Changes in host immune response during the treatment of A. baumannii with novel antibacterial drugs
Keywords: Acinetobacter, molecular epidemiology, antibiotic resistance mechanism, novel antibacterial drugs
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.