Germline stem cells (GSCs) are a rare germ cell population residing in gonads retaining the capacities to self-renew and to differentiate into functional gametes. Dysfunction of GSCs leads to severe reproductive obstacles. In past decades, GSCs isolation, purification, identification and transplantation were successfully established, and characteristics of GSCs are being gradually demonstrating. However, the mechanisms of GSCs self-renewal and differentiation are still largely unknown, especially the regulation of GSCs homeostasis by microenvironment. Recent years, new techniques, e.g., omics, organoid, accelerate the research of stem cell biology and clinic usage. To further reveal the mechanisms behind these biological events and find alternative strategy for clinic therapy, we propose this research topic to report the latest progresses on GSCs research, and clinic relevance.
This topic aims to update the latest progresses in the mechanisms of GSCs biology and the potential of GSCs in translational medicine, including regulation of self-renewal, gametogenesis and relevant disease, to strengthen our understanding in the biological mechanism of controlling fate of GSCs, and to obtain new insights into the treatment of human or animal infertility. We look for advances in fundamental research on GSCs characteristics and translational usage in clinic. Application of new techniques in GSCs research or clinic therapy are encouraged, such as high-throughput sequencing, high resolution imaging and organoid. And reviews expatiating the achievements in GSCs research and relevant reproductive medicine are also welcome.
The topics of interest for this thematic issue aims at gathering reviews and research articles including, but are not limited to, the following themes:
• Animal model or cell model for diseases
• Biological mechanism of germline stem cell fate
• Cell therapy of infertility
• Female germline stem cells
• Gametogenesis
• Germline stem cell associated diseases
• Organoids of testis/ovary
• Omics in germline stem cells
• Epigenetics in stem cell biology
• Microenvironment of germline stem cells
• Novel technology in germline stem cells
• Spermatogonial stem cells
Germline stem cells (GSCs) are a rare germ cell population residing in gonads retaining the capacities to self-renew and to differentiate into functional gametes. Dysfunction of GSCs leads to severe reproductive obstacles. In past decades, GSCs isolation, purification, identification and transplantation were successfully established, and characteristics of GSCs are being gradually demonstrating. However, the mechanisms of GSCs self-renewal and differentiation are still largely unknown, especially the regulation of GSCs homeostasis by microenvironment. Recent years, new techniques, e.g., omics, organoid, accelerate the research of stem cell biology and clinic usage. To further reveal the mechanisms behind these biological events and find alternative strategy for clinic therapy, we propose this research topic to report the latest progresses on GSCs research, and clinic relevance.
This topic aims to update the latest progresses in the mechanisms of GSCs biology and the potential of GSCs in translational medicine, including regulation of self-renewal, gametogenesis and relevant disease, to strengthen our understanding in the biological mechanism of controlling fate of GSCs, and to obtain new insights into the treatment of human or animal infertility. We look for advances in fundamental research on GSCs characteristics and translational usage in clinic. Application of new techniques in GSCs research or clinic therapy are encouraged, such as high-throughput sequencing, high resolution imaging and organoid. And reviews expatiating the achievements in GSCs research and relevant reproductive medicine are also welcome.
The topics of interest for this thematic issue aims at gathering reviews and research articles including, but are not limited to, the following themes:
• Animal model or cell model for diseases
• Biological mechanism of germline stem cell fate
• Cell therapy of infertility
• Female germline stem cells
• Gametogenesis
• Germline stem cell associated diseases
• Organoids of testis/ovary
• Omics in germline stem cells
• Epigenetics in stem cell biology
• Microenvironment of germline stem cells
• Novel technology in germline stem cells
• Spermatogonial stem cells
