Parkinson's syndrome is a clinical syndrome caused by many causes, including motor retardation, stiffness, resting tremor, and postural instability. It mainly includes primary Parkinson's disease, Parkinson's superposition syndrome, secondary Parkinson's syndrome, and hereditary Parkinson's syndrome. The common mode of disease development in this kind of patient is concealed onset, gradual progress, and little natural remission. Presently, non-motor symptoms of Parkinson's syndrome are widely diagnosed and may represent a sensitive predictor of Parkinson's syndrome. However, early diagnosis and the underlying mechanism for non-motor symptoms of Parkinson's syndrome are for the most part unknown.
Non-motor symptoms of Parkinson's syndrome mainly include neuropsychiatric symptoms (anxiety and depression, cognitive impairment, impulse control disorder, apathy), autonomic nervous dysfunction (postural hypotension, chronic constipation, drug-related anorexia, nausea, vomiting, salivation, urinary dysfunction, erectile dysfunction), sleep awakening disorder (insomnia, excessive daytime drowsiness, sleep behavior disorder during rapid eye movement), pain, fatigue, etc. Those clinical manifestations have brought a great influence on the patient's life. Meantime, it is more likely to be misdiagnosed in the early stages, thus delaying the best time for treatment. Furthermore, the pathogenesis of non-motor symptoms of Parkinson's syndrome mainly refers to the pathogenesis of prodromal and clinical non-motor symptoms of patients with Parkinson's syndrome, including basic molecular studies related to blood, cerebrospinal fluid, and tissue markers, as well as genetic, neuroelectrophysiological and neuroimaging studies. A better understanding of the development of non-motor symptoms of Parkinson's syndrome may contribute to early diagnosis, delay progress, and allow for better treatment.
This Research Topic aims to study the pathogenesis and early diagnosis of non-motor symptoms of Parkinson's syndrome (primary Parkinson's disease, Parkinson's superposition syndrome, secondary Parkinson's syndrome, and hereditary Parkinson's syndrome), as well as the latest progress in treatment. We welcome submissions of Clinical Original Research (randomized controlled trials, cohort studies, cross-sectional studies, etc.), Basic Original Research, System Review, meta-analysis, Comments, Mini Comments, and Viewpoints, pertaining but not limited to the following sub-topics:
- Clinical manifestations, symptoms, and diagnostic features of non-motor symptoms of Parkinson's syndrome
- Pathogenesis of non-motor symptoms of Parkinson's syndrome, including blood biomarkers, cerebrospinal fluid, and tissue markers, as well as genetic, neurophysiology, and neuroimaging data
- Describe the macro and microstructures of non-motor symptoms such as anxiety, depression, cognitive impairment, and sleep disturbance in Parkinson's syndrome
- To describe the application value of the questionnaire, olfactory test, transcranial substantia nigra ultrasonography, and polysomnography (PSG) in non-motor symptoms of Parkinson's syndrome
Parkinson's syndrome is a clinical syndrome caused by many causes, including motor retardation, stiffness, resting tremor, and postural instability. It mainly includes primary Parkinson's disease, Parkinson's superposition syndrome, secondary Parkinson's syndrome, and hereditary Parkinson's syndrome. The common mode of disease development in this kind of patient is concealed onset, gradual progress, and little natural remission. Presently, non-motor symptoms of Parkinson's syndrome are widely diagnosed and may represent a sensitive predictor of Parkinson's syndrome. However, early diagnosis and the underlying mechanism for non-motor symptoms of Parkinson's syndrome are for the most part unknown.
Non-motor symptoms of Parkinson's syndrome mainly include neuropsychiatric symptoms (anxiety and depression, cognitive impairment, impulse control disorder, apathy), autonomic nervous dysfunction (postural hypotension, chronic constipation, drug-related anorexia, nausea, vomiting, salivation, urinary dysfunction, erectile dysfunction), sleep awakening disorder (insomnia, excessive daytime drowsiness, sleep behavior disorder during rapid eye movement), pain, fatigue, etc. Those clinical manifestations have brought a great influence on the patient's life. Meantime, it is more likely to be misdiagnosed in the early stages, thus delaying the best time for treatment. Furthermore, the pathogenesis of non-motor symptoms of Parkinson's syndrome mainly refers to the pathogenesis of prodromal and clinical non-motor symptoms of patients with Parkinson's syndrome, including basic molecular studies related to blood, cerebrospinal fluid, and tissue markers, as well as genetic, neuroelectrophysiological and neuroimaging studies. A better understanding of the development of non-motor symptoms of Parkinson's syndrome may contribute to early diagnosis, delay progress, and allow for better treatment.
This Research Topic aims to study the pathogenesis and early diagnosis of non-motor symptoms of Parkinson's syndrome (primary Parkinson's disease, Parkinson's superposition syndrome, secondary Parkinson's syndrome, and hereditary Parkinson's syndrome), as well as the latest progress in treatment. We welcome submissions of Clinical Original Research (randomized controlled trials, cohort studies, cross-sectional studies, etc.), Basic Original Research, System Review, meta-analysis, Comments, Mini Comments, and Viewpoints, pertaining but not limited to the following sub-topics:
- Clinical manifestations, symptoms, and diagnostic features of non-motor symptoms of Parkinson's syndrome
- Pathogenesis of non-motor symptoms of Parkinson's syndrome, including blood biomarkers, cerebrospinal fluid, and tissue markers, as well as genetic, neurophysiology, and neuroimaging data
- Describe the macro and microstructures of non-motor symptoms such as anxiety, depression, cognitive impairment, and sleep disturbance in Parkinson's syndrome
- To describe the application value of the questionnaire, olfactory test, transcranial substantia nigra ultrasonography, and polysomnography (PSG) in non-motor symptoms of Parkinson's syndrome
