Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels, which severely affects the quality of life and survival of patients. The latest data from the International Diabetes Federation showed that there are approximately 537 million diabetic patients globally in 2021, and it is expected to reach 783 million by 2045. The treatment regime of diabetic patients mainly refers to the management of blood glucose and its complications. At present, typical hypoglycemic medications include insulin and non-insulin hypoglycemic drugs, which can be subdivided into a-glucosidase inhibitors, metformin, thiazolidinediones, sulfonylureas, glinides, DPP-4i, GLP-1RA, and SGLT-2i. Diabetic patients with poor islet function usually require insulin replacement, but the majority of patients fail to meet ideal therapeutic targets with multiple hypoglycemic drug combinations (including insulin). Furthermore, poor glycemic control is closely associated with an increased risk of diabetes complications, consequently an increased rate of mortality. More recently, promising new drugs and therapies emerged, which have many other important benefits beyond glucose-lowering. In addition, some traditional Chinese medicine have gradually revealed their therapeutic advantages. All of them provide more choices for the treatment of diabetes patients.
There is still a huge gap between ideal and actual glycemic control. Fortunately, researchers are constantly discovering novel treatments to improve diabetes and its related complications. Therefore, this Research Topic aims to explore or determine new therapies for diabetes, including novel hypoglycemic drugs, new treatment strategies and the management of diabetic complications. We hope to have a refining understanding about the frontiers of diabetes with more in-depth research conducted.
We are interested in submissions of Original Research papers and Review articles, including basic research, clinical research, development and application of translational medicine, meta-analyses, commentaries, and reviews. Potential topics include but are not restricted to:
• Oral insulin that potentially offers non-invasive treatment and better glycemic control in diabetes;
• Novel compound preparation, like IDegLira;
• Stem cell therapy is an effective treatment for diabetes, which varies in types of stem cells and efficacy profile;
• Understanding how traditional Chinese medicine regulate glucose metabolism and provide benefits;
• Clinical trials or fundamental research to explore novel targets in diabetic complications;
• Recent development in promising approaches for glucose management.
Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels, which severely affects the quality of life and survival of patients. The latest data from the International Diabetes Federation showed that there are approximately 537 million diabetic patients globally in 2021, and it is expected to reach 783 million by 2045. The treatment regime of diabetic patients mainly refers to the management of blood glucose and its complications. At present, typical hypoglycemic medications include insulin and non-insulin hypoglycemic drugs, which can be subdivided into a-glucosidase inhibitors, metformin, thiazolidinediones, sulfonylureas, glinides, DPP-4i, GLP-1RA, and SGLT-2i. Diabetic patients with poor islet function usually require insulin replacement, but the majority of patients fail to meet ideal therapeutic targets with multiple hypoglycemic drug combinations (including insulin). Furthermore, poor glycemic control is closely associated with an increased risk of diabetes complications, consequently an increased rate of mortality. More recently, promising new drugs and therapies emerged, which have many other important benefits beyond glucose-lowering. In addition, some traditional Chinese medicine have gradually revealed their therapeutic advantages. All of them provide more choices for the treatment of diabetes patients.
There is still a huge gap between ideal and actual glycemic control. Fortunately, researchers are constantly discovering novel treatments to improve diabetes and its related complications. Therefore, this Research Topic aims to explore or determine new therapies for diabetes, including novel hypoglycemic drugs, new treatment strategies and the management of diabetic complications. We hope to have a refining understanding about the frontiers of diabetes with more in-depth research conducted.
We are interested in submissions of Original Research papers and Review articles, including basic research, clinical research, development and application of translational medicine, meta-analyses, commentaries, and reviews. Potential topics include but are not restricted to:
• Oral insulin that potentially offers non-invasive treatment and better glycemic control in diabetes;
• Novel compound preparation, like IDegLira;
• Stem cell therapy is an effective treatment for diabetes, which varies in types of stem cells and efficacy profile;
• Understanding how traditional Chinese medicine regulate glucose metabolism and provide benefits;
• Clinical trials or fundamental research to explore novel targets in diabetic complications;
• Recent development in promising approaches for glucose management.