Infectious diseases caused by viral infections are major threats to sustainable agriculture and the One Health topic. Emerging viral pathogens in livestock including Newcastle diseases virus (NDV), avian or swine influenza virus (AIV or SIV), African swine fever virus (ASFV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV), and Foot and Mouth Disease Virus (FMDV) have caused enormous economic losses to farmers and the industry. Meanwhile, zoonotic viruses, such as human-origin porcine delta coronavirus (Hu-PDCoV) and novel canine-porcine-feline recombinant alphacoronavirus isolated from human pneumonia patients, raised potential public health risks. To date, vaccination remains the most effective measure to prevent and control veterinary viral infections. However, there are two major concerns in the application of veterinary vaccines: efficacy and safety. Recent advances in vaccinology sciences including reverse genetics, structural modeling of antigens, new adjuvants, and novel delivery systems, provide more approaches for vaccine development. However, there still needs a better understanding of the rational design of vaccines that can provide both effective protection and safety in the field.
Despite significant advances that have been made in the vaccine field, there are still gaps in many aspects, such as pathogen variability, low antigenicity-related vaccination failure as well as virulent reversion of vaccine strains-associated safety concerns. The aim of this Research Topic is to highlight and stimulate discussion regarding vaccine development in animal viruses to provide insights into the prevention and control of emerging or re-emerging animal viruses of economic or public health importance. We encourage researchers to publish their experimental results and systemic reviews focusing on but not limited to the aspects below:
• Novel vaccines development
• New adjuvants and vaccine delivery system
• Structural modeling and design of vaccine antigens
• Viral genetic determinants of virulence
• Host immune responses to vaccination
• Novel in vitro or non-murine animal models for vaccines evaluation
Infectious diseases caused by viral infections are major threats to sustainable agriculture and the One Health topic. Emerging viral pathogens in livestock including Newcastle diseases virus (NDV), avian or swine influenza virus (AIV or SIV), African swine fever virus (ASFV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV), and Foot and Mouth Disease Virus (FMDV) have caused enormous economic losses to farmers and the industry. Meanwhile, zoonotic viruses, such as human-origin porcine delta coronavirus (Hu-PDCoV) and novel canine-porcine-feline recombinant alphacoronavirus isolated from human pneumonia patients, raised potential public health risks. To date, vaccination remains the most effective measure to prevent and control veterinary viral infections. However, there are two major concerns in the application of veterinary vaccines: efficacy and safety. Recent advances in vaccinology sciences including reverse genetics, structural modeling of antigens, new adjuvants, and novel delivery systems, provide more approaches for vaccine development. However, there still needs a better understanding of the rational design of vaccines that can provide both effective protection and safety in the field.
Despite significant advances that have been made in the vaccine field, there are still gaps in many aspects, such as pathogen variability, low antigenicity-related vaccination failure as well as virulent reversion of vaccine strains-associated safety concerns. The aim of this Research Topic is to highlight and stimulate discussion regarding vaccine development in animal viruses to provide insights into the prevention and control of emerging or re-emerging animal viruses of economic or public health importance. We encourage researchers to publish their experimental results and systemic reviews focusing on but not limited to the aspects below:
• Novel vaccines development
• New adjuvants and vaccine delivery system
• Structural modeling and design of vaccine antigens
• Viral genetic determinants of virulence
• Host immune responses to vaccination
• Novel in vitro or non-murine animal models for vaccines evaluation