A common feature of cancer metabolism is the ability to obtain essential nutrients from a nutrient-poor environment and use them to maintain viability as well as generate new biomass. Alterations in intracellular and extracellular metabolites can be accompanied by tumor-associated metabolic reprogramming with profound effects on gene expression, cell differentiation, and tumor microenvironment. In these cases, the metabolic microenvironment of the tumor itself can present an immunosuppressive environment that needs to be overcome. Specifically, it will help maximize the efficacy of cancer therapies by identifying targets that suppress or alter cancer metabolism to improve the tumor microenvironment nutrient availability or that modulate immune metabolism to bolster inflammation.
Cellular senescence is defined as an irreversible life process that combines the decline and disorder of physiological functions during the degradative phase of the body. There is an interaction between cancer cells and senescence in the immune microenvironment. However, there are conflicting conclusions in different types of cancer at present. Therefore, it is important to explore the role of cellular senescence in the tumor microenvironment, which could provide a basis for further targeting senescence immunity therapy in tumors.
This Research Topic aims to explore current strategies and molecular targets under investigation to modulate immune metabolism in the tumor microenvironment. It will help advance the translation process by improving the understanding of these therapeutic targets through both mechanistic and global systems-level views of the heterogenous tumor microenvironment. In addition, these findings could facilitate further understanding of the potential regulatory framework of metabolism and senescence in the tumor microenvironment, and provide novel insights and personalized treatment strategies for cancer immunotherapy.
We welcome Original Research, Reviews, and Methods on the latest achievements about metabolic and senescence characteristics associated with the immune microenvironment in tumor cells. Potential sub-topics may include but are not limited to:
• Construction and screening of metabolic and senescence-related tumor prediction models based on various models;
• Screening and analysis based on metabolomics, proteomics, metabolomics, radiomics, and pathomics;
• Analysis of immune regulatory networks and mechanisms of key metabolism and senescence-targeted factors.
A common feature of cancer metabolism is the ability to obtain essential nutrients from a nutrient-poor environment and use them to maintain viability as well as generate new biomass. Alterations in intracellular and extracellular metabolites can be accompanied by tumor-associated metabolic reprogramming with profound effects on gene expression, cell differentiation, and tumor microenvironment. In these cases, the metabolic microenvironment of the tumor itself can present an immunosuppressive environment that needs to be overcome. Specifically, it will help maximize the efficacy of cancer therapies by identifying targets that suppress or alter cancer metabolism to improve the tumor microenvironment nutrient availability or that modulate immune metabolism to bolster inflammation.
Cellular senescence is defined as an irreversible life process that combines the decline and disorder of physiological functions during the degradative phase of the body. There is an interaction between cancer cells and senescence in the immune microenvironment. However, there are conflicting conclusions in different types of cancer at present. Therefore, it is important to explore the role of cellular senescence in the tumor microenvironment, which could provide a basis for further targeting senescence immunity therapy in tumors.
This Research Topic aims to explore current strategies and molecular targets under investigation to modulate immune metabolism in the tumor microenvironment. It will help advance the translation process by improving the understanding of these therapeutic targets through both mechanistic and global systems-level views of the heterogenous tumor microenvironment. In addition, these findings could facilitate further understanding of the potential regulatory framework of metabolism and senescence in the tumor microenvironment, and provide novel insights and personalized treatment strategies for cancer immunotherapy.
We welcome Original Research, Reviews, and Methods on the latest achievements about metabolic and senescence characteristics associated with the immune microenvironment in tumor cells. Potential sub-topics may include but are not limited to:
• Construction and screening of metabolic and senescence-related tumor prediction models based on various models;
• Screening and analysis based on metabolomics, proteomics, metabolomics, radiomics, and pathomics;
• Analysis of immune regulatory networks and mechanisms of key metabolism and senescence-targeted factors.