As the aging population degree is deepened, cognitive impairment has become a globally recognized public health problem. As an intermediate state from normal cognition (NC) to Alzheimer's disease (AD), mild cognitive impairment (MCI) has a highly variable cognitive trajectory, which contains three outcomes: 1) progression to AD and other types of dementia; 2) Maintaining stability; 3) Reversal to NC. Reversal of cognitive function can be achieved by taking positive and effective measures. Current studies mostly focus on factors affecting MCI to AD. World Health Organization and Alzheimer’s Disease International have also proposed relatively mature guidelines for risk factors. However, there are still some influencing factors that have not yet formed a unified conclusion. In addition, there are fewer studies and no consensus on the influencing factors for MCI to NC. Current forms of intervention for MCI are mainly non-pharmacological interventions, and there is a lack of randomized controlled trials with larger sample sizes and longer intervention periods to confirm the effect of pharmacological and non-pharmacological interventions.The purpose of this study is to explore the factors that influence the transition from MCI to AD or NC in aging adults, and to examine how the influencing factors make the cognitive function of aging adults with MCI deteriorate, improve or even reverse to NC and how are their reversal rates. This includes effective measures proven through pharmacological and non-pharmacological intervention studies and their impact on reversal. Influence factors include but are not limited to demographic factors (age, socioeconomic status, education), lifestyle (smoking, alcohol consumption, physical activity, nutrition, social participation), mental health (depression, loneliness), diseases (hypertension, diabetes, sleep disorders), biological markers (β-amyloid, tau protein), and pharmacological factors (cholinesterase inhibitor, Aβ monoclonal antibodies, drugs to rebalance the gut flora), etc., and submission of research results based on intervention trials is encouraged.Topics of interest include but are not limited to:1. How socio-demographic, lifestyle, mental health, disease, medication, and other factors affect the deterioration or improvement of cognitive function in MCI patients2. Intervention effects of behavioral, lifestyle, and other non-pharmacological interventions alone or in combination on older adults MCI.3. Effectiveness of pharmacological interventions alone or in combination with multiple drugs on MCI in aging people.4. Intervention effects of pharmacological intervention and combined non-pharmacological intervention on MCI in aging people.5. Mechanisms of influencing factors leading to changes in brain cognitive function.6. Summarizing the existing research results of MCI influencing factors (systematic review or meta-analysis)
As the aging population degree is deepened, cognitive impairment has become a globally recognized public health problem. As an intermediate state from normal cognition (NC) to Alzheimer's disease (AD), mild cognitive impairment (MCI) has a highly variable cognitive trajectory, which contains three outcomes: 1) progression to AD and other types of dementia; 2) Maintaining stability; 3) Reversal to NC. Reversal of cognitive function can be achieved by taking positive and effective measures. Current studies mostly focus on factors affecting MCI to AD. World Health Organization and Alzheimer’s Disease International have also proposed relatively mature guidelines for risk factors. However, there are still some influencing factors that have not yet formed a unified conclusion. In addition, there are fewer studies and no consensus on the influencing factors for MCI to NC. Current forms of intervention for MCI are mainly non-pharmacological interventions, and there is a lack of randomized controlled trials with larger sample sizes and longer intervention periods to confirm the effect of pharmacological and non-pharmacological interventions.The purpose of this study is to explore the factors that influence the transition from MCI to AD or NC in aging adults, and to examine how the influencing factors make the cognitive function of aging adults with MCI deteriorate, improve or even reverse to NC and how are their reversal rates. This includes effective measures proven through pharmacological and non-pharmacological intervention studies and their impact on reversal. Influence factors include but are not limited to demographic factors (age, socioeconomic status, education), lifestyle (smoking, alcohol consumption, physical activity, nutrition, social participation), mental health (depression, loneliness), diseases (hypertension, diabetes, sleep disorders), biological markers (β-amyloid, tau protein), and pharmacological factors (cholinesterase inhibitor, Aβ monoclonal antibodies, drugs to rebalance the gut flora), etc., and submission of research results based on intervention trials is encouraged.Topics of interest include but are not limited to:1. How socio-demographic, lifestyle, mental health, disease, medication, and other factors affect the deterioration or improvement of cognitive function in MCI patients2. Intervention effects of behavioral, lifestyle, and other non-pharmacological interventions alone or in combination on older adults MCI.3. Effectiveness of pharmacological interventions alone or in combination with multiple drugs on MCI in aging people.4. Intervention effects of pharmacological intervention and combined non-pharmacological intervention on MCI in aging people.5. Mechanisms of influencing factors leading to changes in brain cognitive function.6. Summarizing the existing research results of MCI influencing factors (systematic review or meta-analysis)