About this Research Topic
The tumor microenvironment (TME), a dynamical changing ecosystem surrounding tumoral cells, provides constantly, positively or negatively influence in tumorigenesis. The interaction of TME and tumoral cells are deeply driven by several powerful oncogenes or tumor suppressors. One of crucial ways to control these “king” genes expression is by consistent and sensitive epigenetic modification of chromatin, specifically histone modification. Histone modification, a crucial epigenetic modification in controlling whether chromatin is “open” or “closed”, plays critical roles in cancer development. Particularly, its dynamic changes powerfully and functionally contribute to reshape the tumor microenvironment. During the reprogramming of TME, RNA binding proteins (CBPs) with their original RNA functions regulate and control post-transcriptional of RNA, contributing to histone modification. The dynamical interaction of histone modification and CBPs gradually establish the intensive, immune-skipping and -suppressing environment in tumor development. However, the profiling relationship of histone modification and CBPs in TME is still not clarified.
The aim of this Research Topic is to investigate the basic relationship and function of histone modification and CBPs in TME by asking how do cancer cells initially trigger CBP-guiding histone modification and globally modulate gene profiling in TME and cancer cells? In feed-back loops, how do cancer cells interacting with stromal cells benefit the reprogramming of TME and stablish supportive and progressive TME, as result, promoting tumor progression. We also will prospect to identify or develop novel drugs that can switch the suppressive TME to more drug sensitive TME through targeting crucial CBPs or histone modification enzymes.
Original Research Articles, Reviews and Mini Reviews, although relevant manuscripts of any type accepted by the journal will be considered, in this research topic. Submissions should consider, but are not limited to, the following topics:
(1) Identify, profile and validate the histone modification in tumor development.
(2) The dynamic relationship of CBPs and histone modification in TME.
(3) Roles of CBPs and histone modification in TME.
(4) Development or design novel drugs that target the specific CBPs or histone modification enzymes for cancer disease.
We accept different article types including Perspectives and Opinions. A full list of accepted article types, including descriptions, can be found at this link.
The aim of this Research Topic is to investigate the basic relationship and function of histone modification and CBPs in TME by asking how do cancer cells initially trigger CBP-guiding histone modification and globally modulate gene profiling in TME and cancer cells? In feed-back loops, how do cancer cells interacting with stromal cells benefit the reprogramming of TME and stablish supportive and progressive TME, as result, promoting tumor progression. We also will prospect to identify or develop novel drugs that can switch the suppressive TME to more drug sensitive TME through targeting crucial CBPs or histone modification enzymes.
Original Research Articles, Reviews and Mini Reviews, although relevant manuscripts of any type accepted by the journal will be considered, in this research topic. Submissions should consider, but are not limited to, the following topics:
(1) Identify, profile and validate the histone modification in tumor development.
(2) The dynamic relationship of CBPs and histone modification in TME.
(3) Roles of CBPs and histone modification in TME.
(4) Development or design novel drugs that target the specific CBPs or histone modification enzymes for cancer disease.
We accept different article types including Perspectives and Opinions. A full list of accepted article types, including descriptions, can be found at this link.
Keywords: histone modification, RNA binding proteins, tumour microenvironment
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