About this Research Topic
The relationship between chromatin structure and gene regulation remains an issue of open debate due to apparent discrepancies between different approaches and model systems. Strong evidence for the importance of genome architecture for correct gene expression comes from studies showing that the disruption of 3D structure in particular loci, either by genomic rearrangements or alterations in TAD boundaries, lead to pathological situations, including developmental disorders or cancer. On the other hand, studies attempting the genome-wide removal of architectural proteins have led to variable effects on gene expression depending on the model system. In addition, the precise dynamics of chromatin structure at different levels and its correlation with gene regulation is also a matter of active debate in the field and we know little about this cause-effect relationship in development.
In this Research Topic, we welcome original articles, reviews and perspectives on different aspects exploring the relationship between chromatin structure and gene regulation, with a focus on developmental processes. Articles may correspond with any of the following topics:
• Epigenomics in development
• Gene regulatory networks controlling development
• Principles of chromatin architecture
• Role of chromatin structure in transcriptional control
• Importance of chromatin folding for human disease
• The 3D genome and evolution
A full list of accepted article types, including descriptions, can be found at this link.
Keywords: Chromatin 3D structure, Epigenomics, Gene Regulation, Development, Disease, Evolution
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.