About this Research Topic
This diversity of haematopoietic niches from embryonic development to adult homeostasis, aging and disease highlights how haematopoiesis is a highly plastic yet tightly orchestrated process. Nevertheless, molecular mechanisms and biochemical cues promoting haematopoiesis are still poorly understood. Decoding the plasticity of the haematopoietic niche represents the key to develop more effective treatments for haematological diseases, including the reliable expansion of donor HSCs in vitro or their production de novo from human pluripotent stem cells as a source of transplantable cells.
This Research Topic aims to assemble original Research Articles, Reviews and Perspectives highlighting the latest advances in the study of developmental and adult haematopoiesis.
Areas to be covered include, but are not limited to:
- Haematopoietic niches during embryonic development, from the yolk sac and dorsal aorta, to the foetal liver and bone marrow.
- The bone marrow microenvironment and secondary haematopoietic sites in adult health, aging and disease.
- Molecular mechanisms and biochemical cues promoting haematopoietic stem and progenitor cell generation, self-renewal and differentiation.
- Novel strategies and technologies to study the haematopoietic niche, including spatial multi-omics approaches and large-scale drug screenings.
- The diversity of model systems to study haematopoiesis, from animal embryos to human pluripotent stem cells.
Keywords: haematopoiesis, haematopoietic niche, haematopoietic stem cells, adult haematopoiesis, haematopoietic
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.