About this Research Topic
The pericentriolar material that surrounds the centrioles and the structures associated with the centriolar cylinders, such as the distal and subdistal appendages and satellites, play an important role in the centrosome's functions in the cell. The centrosome is the center of microtubule organization, and intracellular motors transport individual molecules or even entire organelles along these microtubules.
This organelle is associated with the cell nucleus, and close to the Golgi complex. It is therefore not surprising that many regulatory molecules are concentrated at the centrosome, where they interact with each other.
In recent times, the advent of cutting-edge microscopy techniques and advanced protein analysis has paved to new insights into the world of regulatory protein complexes within the centrosome. These complex entities, nestled within the centrosome, orchestrate and guide a multitude of essential intracellular processes. However, it is worth noting that the linkage between these novel findings and classical ultrastructural studies of centrosome morphology remains a captivating frontier yet to be fully explored.
The purpose of this Research Topic is to introduce readers to various aspects of centrosome research. This collection will help answer the most pressing questions related to the centrosome’s function, structure, and evolution.
Areas of interest may include but are not limited to:
1) How is the regulation of events in the cellular and centriolar cycles related?
2) How procentrioles can form without connection with pre-existing centrioles;
3) Why during the cell cycle doubling of centrioles occurs only once;
4) Why only one procentriole is formed on each mother centriole;
5) How centrioles form during early embryonic development;
6) How is the growth of microtubules at the centrosome regulated;
7) How other cytoskeletal structures of the cell are connected to the centrosome-actin network and the network of intermediate filaments;
8) What morphological variants of centrioles exist in different organisms;
9) How centrioles were transformed during evolution;
10) How the process of formation of cilia and flagella occurs.
We accept different article types including Mini-Reviews, Brief Research Reports, and Perspectives. A full list of accepted article types, including descriptions, can be found at this link.
Topic Editor Dr. Avidor Reiss is affiliated with the University of Toledo that has filed provisional patent application number 63/117,056 for FRAC technology. Dr. Avidor Reiss is also currently on the scientific panel of QART Medical. All other Topic Editors declare no competing interests with regard to the Research Topic subject
Keywords: centrosome, cell cycle, microtubules, cytoskeleton, cilia, flagella
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