Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy

224.8K

views

72

authors

15

articles

Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy

224.8K

views

72

authors

15

articles

Editorial

15 May 2020

Editorial: Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy

Salem Chouaib

and

James Lorens

4,848 views

4 citations

Editors

2

Institut Gustave Roussy

University of Bergen

Impact

About

The microenvironment of a developing tumor is composed of proliferating tumor cells, the tumor stroma, blood vessels, infiltrating inflammatory cells and a variety of associated tissue cells. Accumulating evidence indicates that the crosstalk between stroma cells and malignant cells within this environment crucially determines the fate of tumor progression, its hostility and heterogeneity. A better knowledge of the key suppressive and resistance mechanisms associated with the complexity of tumor microenvironment should therefore provide the means to tailor treatments and develop new combinatorial therapeutic strategies.

Although immune checkpoint blockers on T cells result in significantly improved survival in various metastatic cancer types, a large fraction of cancer patients fail to respond to these therapeutic interventions. In this regard, it has become clear that immunotherapies can be more effective by combining with agents that modulate the tumor microenvironment and modifying the tumor microenvironment to elaborate new strategies for immunotherapy is at present very challenging.

The aim of this Research Topic is to provide a comprehensive review covering the most recent developments in our understanding of the influence of the tumor microenvironment on tumor resistance and suppression with a particular focus on the most effective current therapeutic strategies to target molecules, metabolites and cells that create and sustain the immune hostile tumor microenvironment.

The microenvironment of a developing tumor is composed of proliferating tumor cells, the tumor stroma, blood vessels, infiltrating inflammatory cells and a variety of associated tissue cells. Accumulating evidence indicates that the crosstalk between stroma cells and malignant cells within this environment crucially determines the fate of tumor progression, its hostility and heterogeneity. A better knowledge of the key suppressive and resistance mechanisms associated with the complexity of tumor microenvironment should therefore provide the means to tailor treatments and develop new combinatorial therapeutic strategies.

Although immune checkpoint blockers on T cells result in significantly improved survival in various metastatic cancer types, a large fraction of cancer patients fail to respond to these therapeutic interventions. In this regard, it has become clear that immunotherapies can be more effective by combining with agents that modulate the tumor microenvironment and modifying the tumor microenvironment to elaborate new strategies for immunotherapy is at present very challenging.

The aim of this Research Topic is to provide a comprehensive review covering the most recent developments in our understanding of the influence of the tumor microenvironment on tumor resistance and suppression with a particular focus on the most effective current therapeutic strategies to target molecules, metabolites and cells that create and sustain the immune hostile tumor microenvironment.

Download ebook

Share

Editors

Institut Gustave Roussy

University of Bergen

Impact

224,793 Total views

152,336 Article views

68,983 Article downloads

3,474 Topic views

Published In

Journal Thumbnail

Frontiers in Immunology

Cancer Immunity and Immunotherapy

Journal Thumbnail

Frontiers in Oncology

Cancer Immunity and Immunotherapy

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic