About this Research Topic
Although immune checkpoint blockers on T cells result in significantly improved survival in various metastatic cancer types, a large fraction of cancer patients fail to respond to these therapeutic interventions. In this regard, it has become clear that immunotherapies can be more effective by combining with agents that modulate the tumor microenvironment and modifying the tumor microenvironment to elaborate new strategies for immunotherapy is at present very challenging.
The aim of this Research Topic is to provide a comprehensive review covering the most recent developments in our understanding of the influence of the tumor microenvironment on tumor resistance and suppression with a particular focus on the most effective current therapeutic strategies to target molecules, metabolites and cells that create and sustain the immune hostile tumor microenvironment.
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