Cell volume regulation is a fundamental aspect of cellular physiology, essential for maintaining structural integrity and the stability of the internal environment. This regulation is vital for a wide array of cellular functions, including epithelial transport, metabolism, excitation, hormone release, cell migration, proliferation, and cell death. When cells encounter osmotic disturbances, they activate transport pathways, primarily involving channels and transporters for inorganic osmolytes, to manage water flow. Chloride ions, as the most prevalent anions in organisms, play a significant role in various physiological and pathological processes. The volume-regulated anion channel (VRAC) is composed of diverse molecular constituents, suggesting a potential for cell type or tissue-specific subunit components such as LRRC8A-E, CFTR, and others. Despite its primary role as an anion conduit, VRAC is also implicated in cellular signal transduction, gene expression, and protein translocation. Current research has made strides in understanding these processes, yet gaps remain in fully elucidating the complex interactions and functions of VRAC and its related proteins.
This research topic aims to delve into the physiological, pathological, and pathophysiological characteristics of VRAC and its associated genes. The primary objectives include exploring the role and regulation of cell volume in essential cellular functions, investigating the diverse molecular constituents of VRAC, and examining its involvement in cellular signal transduction and other processes. By addressing these questions, the research seeks to expand the current understanding of VRAC's multifaceted roles and its broader implications in cell volume regulation.
To gather further insights into the physiological and pathological roles of VRAC and its related genes, we welcome articles addressing, but not limited to, the following themes:
• Studies exploring the role and regulation of cell volume in key cellular functions such as epithelial transport, metabolism, excitation, hormone release, cell migration, proliferation, and cell death.
• Investigations into the varied molecular constituents of the volume-regulated anion channel (VRAC) and the potential for cell type or tissue-specific subunit components.
• Research that explores the role of VRAC in cellular signal transduction, gene expression, and protein translocation, expanding its known functions beyond acting as an anion channel.
• Contributions focusing on the characteristics, regulations, and functions of VRAC-associated proteins, and related studies concerning cation channels.
Cell volume regulation is a fundamental aspect of cellular physiology, essential for maintaining structural integrity and the stability of the internal environment. This regulation is vital for a wide array of cellular functions, including epithelial transport, metabolism, excitation, hormone release, cell migration, proliferation, and cell death. When cells encounter osmotic disturbances, they activate transport pathways, primarily involving channels and transporters for inorganic osmolytes, to manage water flow. Chloride ions, as the most prevalent anions in organisms, play a significant role in various physiological and pathological processes. The volume-regulated anion channel (VRAC) is composed of diverse molecular constituents, suggesting a potential for cell type or tissue-specific subunit components such as LRRC8A-E, CFTR, and others. Despite its primary role as an anion conduit, VRAC is also implicated in cellular signal transduction, gene expression, and protein translocation. Current research has made strides in understanding these processes, yet gaps remain in fully elucidating the complex interactions and functions of VRAC and its related proteins.
This research topic aims to delve into the physiological, pathological, and pathophysiological characteristics of VRAC and its associated genes. The primary objectives include exploring the role and regulation of cell volume in essential cellular functions, investigating the diverse molecular constituents of VRAC, and examining its involvement in cellular signal transduction and other processes. By addressing these questions, the research seeks to expand the current understanding of VRAC's multifaceted roles and its broader implications in cell volume regulation.
To gather further insights into the physiological and pathological roles of VRAC and its related genes, we welcome articles addressing, but not limited to, the following themes:
• Studies exploring the role and regulation of cell volume in key cellular functions such as epithelial transport, metabolism, excitation, hormone release, cell migration, proliferation, and cell death.
• Investigations into the varied molecular constituents of the volume-regulated anion channel (VRAC) and the potential for cell type or tissue-specific subunit components.
• Research that explores the role of VRAC in cellular signal transduction, gene expression, and protein translocation, expanding its known functions beyond acting as an anion channel.
• Contributions focusing on the characteristics, regulations, and functions of VRAC-associated proteins, and related studies concerning cation channels.