Omics technologies represent a new analytical approach that allows a full cellular readout through the
simultaneous analysis of thousands of molecules. The application of such technologies represents a flourishing field of research in human medicine, especially in transfusion medicine, while their application in veterinary medicine still
needs to be developed.
Summary: Omics technologies, especially proteomics, metabolomics, and lipidomics, are currently applied in several fields of human medicine. In transfusion medicine, the creation and integration of multiomics
datasets have uncovered intricate molecular pathways
occurring within blood bags during storage. In particular, the research has been directed toward the study of storage lesions (SLs), i.e., those biochemical and structural changes that red blood cells (RBCs) undergo during hypothermic storage, their causes, and the development of new strategies to prevent them.
Due to their challenges to perform and high costs, omic technologies are hardly accessible to veterinary research, where their application dates back only
to the last few years and thus a great deal of progress still needs to be made. As regards veterinary medicine, there are only a few studies that have focused mainly on fields such as oncology, nutrition, cardiology, and nephrology. Other studies have suggested omics datasets that provide important insights for future comparative investigations between human
and nonhuman species. Regarding the study of storage
lesions and, more generally, the veterinary transfusion field, there is a marked lack of available omics data and results with relevance for clinical practice.
Omics technologies in human medicine is well established and has led to promising results in blood transfusion and related practices knowledge. Transfusion practice is a burgeoning field in veterinary medicine, but, to date, there are no
species-specific procedures and techniques for the collection and storage of blood units and those validated in the human species are univocally pursued. Multiomics analysis of the species-specific RBCs’ biological characteristics could provide
promising results both from a comparative perspective, by increasing our understanding of species suitable to be used as animal models, and in a strictly veterinary view, by contributing to the development of animal-targeted procedures.
We aim to comparatively study the species-specific omics features of fresh and stored RBCs looking for features with clinical implications in veterinary transfusion medicine. In particular, we will focus on the identification of possible markers usable to select ideal donors, the development of species-specific additive solutions and processing techniques for blood units, the comparative study of SLs in different species and of new strategies to prevent them, and, not least, the
study of potential posttransfusion adverse events in veterinary recipients.
We encourage submissions of original research, reviews and case reports presenting comparative omics findings in the veterinary and comparative hematology and transfusion medicine with particular attention to their application to humans and domestic, exotic and wild animals.
Keywords:
metabolomic, lipidomic, proteomic, genomic, hemathology, transfusion medicine, animals, humans, comparative medicine
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Omics technologies represent a new analytical approach that allows a full cellular readout through the
simultaneous analysis of thousands of molecules. The application of such technologies represents a flourishing field of research in human medicine, especially in transfusion medicine, while their application in veterinary medicine still
needs to be developed.
Summary: Omics technologies, especially proteomics, metabolomics, and lipidomics, are currently applied in several fields of human medicine. In transfusion medicine, the creation and integration of multiomics
datasets have uncovered intricate molecular pathways
occurring within blood bags during storage. In particular, the research has been directed toward the study of storage lesions (SLs), i.e., those biochemical and structural changes that red blood cells (RBCs) undergo during hypothermic storage, their causes, and the development of new strategies to prevent them.
Due to their challenges to perform and high costs, omic technologies are hardly accessible to veterinary research, where their application dates back only
to the last few years and thus a great deal of progress still needs to be made. As regards veterinary medicine, there are only a few studies that have focused mainly on fields such as oncology, nutrition, cardiology, and nephrology. Other studies have suggested omics datasets that provide important insights for future comparative investigations between human
and nonhuman species. Regarding the study of storage
lesions and, more generally, the veterinary transfusion field, there is a marked lack of available omics data and results with relevance for clinical practice.
Omics technologies in human medicine is well established and has led to promising results in blood transfusion and related practices knowledge. Transfusion practice is a burgeoning field in veterinary medicine, but, to date, there are no
species-specific procedures and techniques for the collection and storage of blood units and those validated in the human species are univocally pursued. Multiomics analysis of the species-specific RBCs’ biological characteristics could provide
promising results both from a comparative perspective, by increasing our understanding of species suitable to be used as animal models, and in a strictly veterinary view, by contributing to the development of animal-targeted procedures.
We aim to comparatively study the species-specific omics features of fresh and stored RBCs looking for features with clinical implications in veterinary transfusion medicine. In particular, we will focus on the identification of possible markers usable to select ideal donors, the development of species-specific additive solutions and processing techniques for blood units, the comparative study of SLs in different species and of new strategies to prevent them, and, not least, the
study of potential posttransfusion adverse events in veterinary recipients.
We encourage submissions of original research, reviews and case reports presenting comparative omics findings in the veterinary and comparative hematology and transfusion medicine with particular attention to their application to humans and domestic, exotic and wild animals.
Keywords:
metabolomic, lipidomic, proteomic, genomic, hemathology, transfusion medicine, animals, humans, comparative medicine
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.