About this Research Topic
Since immune tolerance is not innate but is established during fetal life and postnatal development through an array of sophisticated mechanisms that take place essentially in the primary and secondary lymphoid organs, unraveling the pathways that underlie the generation of pathogenic autoimmune reactions has typically focused on the adaptive branch of the immune system, i.e. T cells, B cells, and autoantibodies. Recently, however, many laboratories have demonstrated that innate immunity can also play important roles in the initiation and/or progression of autoimmune disease. A better understanding of innate immune cells and pathways involved could lead to the design of new targeted strategies of immune intervention. This Research Topic aims to provide an overview and discussions of the recent discoveries of how innate immunity influences autoimmune diseases in a series of Review articles.
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