About this Research Topic
Within this view, this research topic welcomes articles in 4 main areas:
1) Understanding Adverse Reactions to Biomaterials: Basic in vitro and in vivo studies elucidating the reactions to biomaterials from single cell to system level.
2) Biomaterial testing systems and methods: New techniques, technologies and methods for physical, mechanical, chemical and biological characterization of biomaterials with a particular emphasis on potential risks pertaining to their use.
3) Immunomodulation: Immunomodulation innovations for mediation of implanted biomaterial host interactions via micro/nanoscale surface modifications, immune-instructive biomaterial design, controlled delivery of cytokines or similar technologies.
4) In vitro models and on-chip systems: In vitro model systems at single organ or connected organs level for studies of biomaterial interactions with tissues.
This Research Topic will be a collection of state-of-the-art research papers together with reviews and mini-reviews as a potential source of reference for the recent advances in risk assessment of biomaterials. Methodology and protocole based studies together with clinical retrorespective studies or meta-analyses of adverse reactions to implanted biomaterials are also seeked.
Keywords: Biomaterials, Immune response, Risk assessment, In vitro models, Micro/Nanotechnology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.