About this Research Topic
The human microbiome is a complex collection of microbes inhabiting many different sites on and in the human body. The recent advances in genomics have enabled deep sequencing and analysis of the members of these communities. Large-scale projects such as the Human Microbiome Project (HMP) and Metagenomics of the Human Intestinal Tract (MetaHIT) enabled comprehensive surveying the collection of microbial genomes and genes.
Now with our increasing ability to understand the metabolic and functional capabilities of microbes related to human, the role of human-associated microbiota in health and disease has received huge attention and appreciation. Therefore it is vital to understand and investigate various symbiotic interactions of the human host and microbiota in maintaining hemeostasis, especially in host-microbiota systems of the gastrointestinal tract and vagina, and how these interactions could lead to dysbiosis.
Furthermore it is vital to understand the function of gastrointestinal microbiota as first line of protection against pathogens, and hosting defense mechanisms to counter pathogenic invasion. As it is alarming how the disturbance of intestinal microbiome is related to digestive diseases including colorectal cancer, gastrointestinal infections and inflammatory bowel diseases. Investigation of the microbiome will pave a way to a better understanding of these human conditions, which has huge potential to be used to improve disease prevention, management and treatment.
Thus the understanding of the human microbiota in relation to human health and disease, and the incorporation of the microbiome is one of the key component fundamental for the advancement of personalized medicine.
This Research Topic will focus on studies (including e.g. original articles, perspectives, reviews, mini reviews, commentaries, opinion papers, data reports) that study and explore these topics but not limited to this list:
1. The elucidation of gastrointestinal microbiome profiles and abundance in human health and disease state
2. The relationships (interplay) between the host and the gastrointestinal microbiota in human health and disease state
3. Gastrointestinal microbiota as first line of protection against pathogens, and hosting defense mechanisms to counter pathogenic invasion
4. The therapeutic potential of microbiome-based approaches for prevention or treatment of human diseases
5. Techniques and strategies for understanding the functional complexity of host–microbe interactions, including but not limited to metagenomics, metatranscriptomics, metaproteomics and metabolomics.
Keywords: microbiome, human health, cancer, diabetes, acute diseases, chronic diseases, metagenomics, metatranscriptomics, metaproteomics, metabolomics
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