Research Topic

Human Microbiome: Symbiosis to Pathogenesis

About this Research Topic

The human microbiome is a complex collection of microbes inhabiting many different sites on and in the human body. The recent advances in genomics have enabled deep sequencing and analysis of the members of these communities. Large-scale projects such as the Human Microbiome Project (HMP) and Metagenomics of ...

The human microbiome is a complex collection of microbes inhabiting many different sites on and in the human body. The recent advances in genomics have enabled deep sequencing and analysis of the members of these communities. Large-scale projects such as the Human Microbiome Project (HMP) and Metagenomics of the Human Intestinal Tract (MetaHIT) enabled comprehensive surveying the collection of microbial genomes and genes.

Now with our increasing ability to understand the metabolic and functional capabilities of microbes related to human, the role of human-associated microbiota in health and disease has received huge attention and appreciation. Therefore it is vital to understand and investigate various symbiotic interactions of the human host and microbiota in maintaining hemeostasis, especially in host-microbiota systems of the gastrointestinal tract and vagina, and how these interactions could lead to dysbiosis.

Furthermore it is vital to understand the function of gastrointestinal microbiota as first line of protection against pathogens, and hosting defense mechanisms to counter pathogenic invasion. As it is alarming how the disturbance of intestinal microbiome is related to digestive diseases including colorectal cancer, gastrointestinal infections and inflammatory bowel diseases. Investigation of the microbiome will pave a way to a better understanding of these human conditions, which has huge potential to be used to improve disease prevention, management and treatment.

Thus the understanding of the human microbiota in relation to human health and disease, and the incorporation of the microbiome is one of the key component fundamental for the advancement of personalized medicine.

This Research Topic will focus on studies (including e.g. original articles, perspectives, reviews, mini reviews, commentaries, opinion papers, data reports) that study and explore these topics but not limited to this list:
1. The elucidation of gastrointestinal microbiome profiles and abundance in human health and disease state
2. The relationships (interplay) between the host and the gastrointestinal microbiota in human health and disease state
3. Gastrointestinal microbiota as first line of protection against pathogens, and hosting defense mechanisms to counter pathogenic invasion
4. The therapeutic potential of microbiome-based approaches for prevention or treatment of human diseases
5. Techniques and strategies for understanding the functional complexity of host–microbe interactions, including but not limited to metagenomics, metatranscriptomics, metaproteomics and metabolomics.


Keywords: microbiome, human health, cancer, diabetes, acute diseases, chronic diseases, metagenomics, metatranscriptomics, metaproteomics, metabolomics


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

15 September 2018 Manuscript
15 December 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

15 September 2018 Manuscript
15 December 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top
);