The production of various metabolites by the gut microbiome crucially influences both health and disease states in the host. In relation to cardiometabolic diseases, key microbial-derived compounds such as trimethylamine N-oxide (TMAO) have been implicated in atherosclerosis development, whereas short-chain fatty acids (SCFAs) play a positive role in enhancing insulin sensitivity. Other metabolites including bile acids and indole derivatives contribute to processes like inflammation and lipid management. Despite these significant discoveries, the overall functional importance of these metabolites alongside their interactions with genetic, dietary, and environmental factors remains poorly defined. This emerging field is poised to revolutionize our approach to understanding and managing cardiometabolic diseases, potentially leading to innovative precision medicine strategies.
This Research Topic aims to decipher the complex interrelationships between bacterial metabolites and cardiometabolic diseases. Our objectives are to delve into how particular metabolites influence disease progression, to pinpoint biomarkers that enhance early disease detection, and to investigate new treatment methods that target the gut microbiome. This collection seeks to fill current knowledge gaps and foster the development of microbiome-centered diagnostics and therapeutic solutions, which are essential for the advancement of prevention and treatment strategies for cardiometabolic illnesses.
To gather further insights specifically in human nutrition, we welcome articles addressing, but not limited to, the following themes:
• The mechanisms connecting bacterial metabolites to the pathogenesis of human cardiometabolic diseases.
• Identification of microbiome-derived biomarkers for early diagnosis of cardiometabolic conditions in humans.
• Novel therapeutic strategies targeting microbial metabolites or aiming to modify the human gut microbiome composition.
• Interactions between diet, lifestyle, and host genetics in shaping human microbial metabolite profiles.
We are particularly interested in the following article types: Original Research, Review, and Perspectives.
The production of various metabolites by the gut microbiome crucially influences both health and disease states in the host. In relation to cardiometabolic diseases, key microbial-derived compounds such as trimethylamine N-oxide (TMAO) have been implicated in atherosclerosis development, whereas short-chain fatty acids (SCFAs) play a positive role in enhancing insulin sensitivity. Other metabolites including bile acids and indole derivatives contribute to processes like inflammation and lipid management. Despite these significant discoveries, the overall functional importance of these metabolites alongside their interactions with genetic, dietary, and environmental factors remains poorly defined. This emerging field is poised to revolutionize our approach to understanding and managing cardiometabolic diseases, potentially leading to innovative precision medicine strategies.
This Research Topic aims to decipher the complex interrelationships between bacterial metabolites and cardiometabolic diseases. Our objectives are to delve into how particular metabolites influence disease progression, to pinpoint biomarkers that enhance early disease detection, and to investigate new treatment methods that target the gut microbiome. This collection seeks to fill current knowledge gaps and foster the development of microbiome-centered diagnostics and therapeutic solutions, which are essential for the advancement of prevention and treatment strategies for cardiometabolic illnesses.
To gather further insights specifically in human nutrition, we welcome articles addressing, but not limited to, the following themes:
• The mechanisms connecting bacterial metabolites to the pathogenesis of human cardiometabolic diseases.
• Identification of microbiome-derived biomarkers for early diagnosis of cardiometabolic conditions in humans.
• Novel therapeutic strategies targeting microbial metabolites or aiming to modify the human gut microbiome composition.
• Interactions between diet, lifestyle, and host genetics in shaping human microbial metabolite profiles.
We are particularly interested in the following article types: Original Research, Review, and Perspectives.