The field of regenerative medicine and immunotherapy closely examines the remodeling of the tissue microenvironment, a dynamic process involving changes in cellular interactions, matrix composition, and cytokine levels crucial for tissue repair and regeneration. Immune cells, integral to the immune system, play pivotal roles not only in defense mechanisms against infections and tumors but also in tissue repair, wound healing, and managing inflammatory responses. They facilitate tissue recovery by clearing necrotic debris and pathogens, and by secreting cytokines, chemokines, and growth factors that recruit and activate other cells. Recent advancements highlight the potential of modulating immune cell behavior to enhance tissue repair, such as through the polarization of immune cells, alterations in the immune microenvironment, or reprogramming immune cell functions, presenting new possibilities for therapeutic strategies.
This Research Topic aims to delve into the roles and mechanisms through which immune cells contribute to tissue repair by altering the immune microenvironment. Investigating these interactions can extend our understanding of immune functions in tissue repair and spearhead innovative approaches in regenerative medicine and immunotherapy. An increased grasp of these dynamics is anticipated to revolutionize therapeutic techniques and improve clinical outcomes in tissue repair interventions.
To gather further insights in this complex interplay, we welcome articles addressing, but not limited to, the following themes:
• Immune cell-mediated modulation of extracellular matrix remodeling in tissue repair.
• Crosstalk of immune cells with other cells in tissue repair and regeneration.
• Novel perspectives on changes in the immune microenvironment during tissue repair.
• Novel therapeutic strategies based on immune regulatory mechanisms.
• Impact of aging on immune cell function in tissue repair.
The field of regenerative medicine and immunotherapy closely examines the remodeling of the tissue microenvironment, a dynamic process involving changes in cellular interactions, matrix composition, and cytokine levels crucial for tissue repair and regeneration. Immune cells, integral to the immune system, play pivotal roles not only in defense mechanisms against infections and tumors but also in tissue repair, wound healing, and managing inflammatory responses. They facilitate tissue recovery by clearing necrotic debris and pathogens, and by secreting cytokines, chemokines, and growth factors that recruit and activate other cells. Recent advancements highlight the potential of modulating immune cell behavior to enhance tissue repair, such as through the polarization of immune cells, alterations in the immune microenvironment, or reprogramming immune cell functions, presenting new possibilities for therapeutic strategies.
This Research Topic aims to delve into the roles and mechanisms through which immune cells contribute to tissue repair by altering the immune microenvironment. Investigating these interactions can extend our understanding of immune functions in tissue repair and spearhead innovative approaches in regenerative medicine and immunotherapy. An increased grasp of these dynamics is anticipated to revolutionize therapeutic techniques and improve clinical outcomes in tissue repair interventions.
To gather further insights in this complex interplay, we welcome articles addressing, but not limited to, the following themes:
• Immune cell-mediated modulation of extracellular matrix remodeling in tissue repair.
• Crosstalk of immune cells with other cells in tissue repair and regeneration.
• Novel perspectives on changes in the immune microenvironment during tissue repair.
• Novel therapeutic strategies based on immune regulatory mechanisms.
• Impact of aging on immune cell function in tissue repair.