About this Research Topic
There are approximately 2000 WW domain-containing proteins in vivo. These proteins are involved in signaling for maintaining normal physiology. WW domains are protein modules that mediate protein-protein interactions through recognition of proline-rich peptide motifs (PRM) and phosphorylated serine/threonine-proline sites. WW domains are found in many different structural and signaling proteins that are involved in a variety of cellular processes. WW domain-containing proteins and complexes have been implicated in major human diseases including cancer as well as in major signaling cascades such as the Hippo tumor suppressor pathway, making them targets for new diagnostics and therapeutics.
Key WW domain proteins such as, but not limited to, the emerging tumor suppressor WWOX has been linked to fundamental processes involved in normal physiology and diseases. Null mutation of WWOX/Wwox gene induces severe neural diseases, metabolic disorders and early death in humans and animals. In this proposed Research Topic, we call for reviews and research articles for WW domain proteins in signaling, cancer and metabolism, covering WWOX and WW domain proteins in the Smad, Wnt, Hippo and other signaling pathways.
Protein networking and signaling is fundamental in biology and disease. WW domains and WW domain-containing proteins play essential roles in these settings. Like many other module-containing proteins, the WW domain is responsible for protein-protein interaction and signal transduction. Recently, there has been tremendous advancement of WW domain biology and events regulated by these interactions. It is therefore of great importance to review the recent and emerging evidence that uncover the significance of these modules and key signaling molecules, such as WWOX and YAP, to achieve better understanding of normal physiology and diseases.
Papers from scientific communities studying protein-protein interactions, signaling, cell biology, immunology, and molecular oncology are welcome. The main topics authors may address include, but are not limited to, the following:
• WWOX gene structure and alterations
• WWOX in signaling and diseases
• WWOX functions in model systems
• WW domain proteins in signaling and diseases
• WW domain in protein/protein interactions
• WW domain protein genetics and diseases
• WW domain proteins in the Hippo pathway
Keywords: WW domain, WWOX, tumor suppressor, Hippo pathway, neural diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.