Host Genetics in Viral Pathogenesis and Controls

173.4K

views

160

authors

22

articles

Editorial

08 November 2019

Editorial: Host Genetics in Viral Pathogenesis and Control

Ping An

,

Ju-Tao Guo

and

Cheryl A. Winkler

8,446 views

5 citations

Editors

3

Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick (NIH)

Baruch S. Blumberg Institute

Cheryl Ann Winkler

Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick (NIH)

Impact

Fetching...

About

Dynamic host-virus interactions determine the outcomes of virus infection, clinical sequelae and prophylactic or therapeutic responses. Host genetic variants in genes involved in viral life cycle and defences against infection affect the fate of viral exposures. Host proviral and antiviral factors have been identified for many medically important viruses, but the role of host genetics for most viruses remains elusive or unexplored. The highly variable outcomes of viral infections are likely attributable to complex interactions between the host and pathogen genetic variation. The identification of host genes and key pathogen-interacting factors by genome-wide genetic, expression, epigenetic profiling and other emerging technologies should provide important insights to combating viral diseases.

This Research Topic aims to present original research, commentaries, and reviews on the state of the art research and the future directions for host-viral interactions.

Specifically, we encourage the submission of reviews, original research reports, methods articles, commentaries and perspectives, in the following (but not limited to) topics:

• Human genetic variations (structural variants, CNVs and SNPs) that affect susceptibility to viral infection and outcomes.

• Host transcriptomic, proteomic, epigenetic changes that shapes viral infections.

• Genetic factors that affect host immune response to vaccine and antiviral therapies.

• Dynamic host-virus genetic interactions driven by selective pressures.

• Functional analyses of host genetic association of viral infections

• Genetic factors that control Innate and adaptive immunity responses to viruses.

• Computational or statistically modelling to address prevention, treatment interventions, and effective control of viral epidemics.

• Utilization of cellular systems, animal models, or single cell analyses to interrogate host genetic control of viral replication and pathogenesis.

• Systems biology approaches integrating the “omics” of infection and host responses.

Dynamic host-virus interactions determine the outcomes of virus infection, clinical sequelae and prophylactic or therapeutic responses. Host genetic variants in genes involved in viral life cycle and defences against infection affect the fate of viral exposures. Host proviral and antiviral factors have been identified for many medically important viruses, but the role of host genetics for most viruses remains elusive or unexplored. The highly variable outcomes of viral infections are likely attributable to complex interactions between the host and pathogen genetic variation. The identification of host genes and key pathogen-interacting factors by genome-wide genetic, expression, epigenetic profiling and other emerging technologies should provide important insights to combating viral diseases.

This Research Topic aims to present original research, commentaries, and reviews on the state of the art research and the future directions for host-viral interactions.

Specifically, we encourage the submission of reviews, original research reports, methods articles, commentaries and perspectives, in the following (but not limited to) topics:

• Human genetic variations (structural variants, CNVs and SNPs) that affect susceptibility to viral infection and outcomes.

• Host transcriptomic, proteomic, epigenetic changes that shapes viral infections.

• Genetic factors that affect host immune response to vaccine and antiviral therapies.

• Dynamic host-virus genetic interactions driven by selective pressures.

• Functional analyses of host genetic association of viral infections

• Genetic factors that control Innate and adaptive immunity responses to viruses.

• Computational or statistically modelling to address prevention, treatment interventions, and effective control of viral epidemics.

• Utilization of cellular systems, animal models, or single cell analyses to interrogate host genetic control of viral replication and pathogenesis.

• Systems biology approaches integrating the “omics” of infection and host responses.

Download ebook

Share

Editors

Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick (NIH)

Baruch S. Blumberg Institute

Cheryl Ann Winkler

Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick (NIH)

Impact

173,443 Total views

124,542 Article views

44,511 Article downloads

4,390 Topic views

Published In

Journal Thumbnail

Frontiers in Genetics

Applied Genetic Epidemiology

Journal Thumbnail

Frontiers in Immunology

Comparative Immunology, Viral Immunology

Journal Thumbnail

Frontiers in Microbiology

Virology, Infectious Agents and Disease

Journal Thumbnail

Frontiers in Plant Science

Journal Thumbnail

Frontiers in Medicine

Infectious Agents and Disease

Journal Thumbnail

Frontiers in Public Health

Infectious Agents and Disease

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic