The Genetic and Environmental Basis for Diseases in Understudied Populations

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Editorial

23 September 2020

Editorial: The Genetic and Environmental Basis for Diseases in Understudied Populations

Nicola Mulder

,

Zané Lombard

,

Mayowa Ojo Owolabi

and

Solomon Fiifi Ofori-Acquah

2,589 views

1 citations

Editors

4

Nicola Mulder

University of Cape Town

Zané Lombard

University of the Witwatersrand

Mayowa Ojo Owolabi

University of Ibadan

Solomon Fiifi Ofori-Acquah

University of Ghana

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About

This Research Topic was realized in collaboration with Research Associate Marusya Lieveld.
Studying the genetic and environmental basis for both communicable and non-communicable diseases has the potential to improve our understanding of these diseases in different populations and to help in the development of novel interventions. Genomic medicine is becoming more feasible with the decreasing costs of DNA genotyping and sequencing. However, the implementation of genomic medicine requires knowledge of the genetic basis of diseases and reference data for the populations under study. Genomic data for human populations in public databases is heavily biased towards Eurasian population groups as they are the most studied groups to date. Some populations, such as those of African descent or indigenous populations have, until recently, not been extensively studied and thus their data are currently under-represented in public repositories. The paucity of data from these understudied populations in public databases limits our knowledge of population-specific genetic variation that influence susceptibility to or protection from human disorders. Understanding local environmental factors are also important as these will impact susceptibility to or protection from multi-factorial diseases.

In this Research Topic we are seeking high quality Original Research papers describing novel insights into genetic and environmental factors that impact disease risk, expression, prognosis and treatment in understudied populations in human genomics research. These include African, Latin American, Indian and other indigenous populations. The specific themes of interest in this special issue include:
- Population genetic studies
- Genome wide association studies
- Epigenetics
- Pharmacogenomics
- Environmental risk factors for diseases
- Gene-environment interactions in diseases
- Microbiome studies related to diseases

The manuscripts should be Original Research articles.

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Editors

Nicola Mulder

University of Cape Town

Zané Lombard

University of the Witwatersrand

Mayowa Ojo Owolabi

University of Ibadan

Solomon Fiifi Ofori-Acquah

University of Ghana

Impact

160,449 Total views

121,985 Article views

35,432 Article downloads

3,032 Topic views

Published In

Frontiers in Genetics

Evolutionary and Population Genetics, Genetics of Common and Rare Diseases

Frontiers in Ecology and Evolution

Evolutionary and Population Genetics

Frontiers in Pediatrics

Genetics of Common and Rare Diseases

Frontiers in Plant Science

Evolutionary and Population Genetics

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