Research Topic

Immunonutrient Supplementation

About this Research Topic

Food represents an antigen for the intestinal immune system, thus eliciting a robust response. However, according to the type of diet such a response can be either detrimental or beneficial to the host. In general terms, the intestinal immune homeostasis is controlled by two cell types, T regulatory (Treg) ...

Food represents an antigen for the intestinal immune system, thus eliciting a robust response. However, according to the type of diet such a response can be either detrimental or beneficial to the host. In general terms, the intestinal immune homeostasis is controlled by two cell types, T regulatory (Treg) cells and T helper (h)-17 cells. Treg cells are a great source of the anti-inflammatory cytokine interleukin (IL)-10, while Th17 cells trigger a potent inflammatory response via release of IL-17. In turn, intestinal microbiota strictly interacts with gut immune cells, thus, driving either pro-inflammatory or anti-inflammatory response. A correct dietary regimen, e.g., Mediterranean diet, leads to a switch of the intestinal immune response toward a tolerogenic pathway. Conversely, junk food is rather pro-inflammatory at intestinal and systemic levels. Nowadays, inappropriate diets have led to an increase of metabolic diseases and especially obesity and diabetes. Therefore, besides a controlled dietary regimen also immunonutrient supplementation may lead to a favorable solution of these medical problems.

Particularly, supplements such as omega-3, pre- probiotics, polyphenols and vitamins A and C share common properties such as normalization of the altered intestinal microbiota and up-regulation of Treg cell function. Moreover, another common pathology is represented by inflammatory bowel disease (IBD) characterized by changes of the microbiota profiles and an exaggerated Th17 cell function. Some of the above cited supplements are very effective in the adjuvant treatment of patients with IBD. Allergic reactions are very spread all over the world and evidence has been provided that polyphenols, as an example of immunonutrient, seem to be very effective in the treatment of these diseases either experimentally or in clinical settings. Finally, immunonutrient supplementation has been shown to be very efficacious in the treatment of immunosenescence and its complications.

In conclusion, this Research Topic will encompass the immunological properties of major nutrients such as omega-3, polyphenols, pre – probiotics, vitamins and oligoelements, on the one hand. On the other hand, clinical trials based on these supplements for the treatment of chronic inflammatory disease such as obesity, cardiovascular pathologies, IBD, autoimmune disease, contact dermatitis and neurodegenerative disease will represent the major topics related to this Research Topic.


Keywords: Omega-3, Prebiotics, Probiotics, Polyphenols, Vitamins


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

31 October 2018 Abstract
31 January 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

31 October 2018 Abstract
31 January 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top
);