Research Topic

New Insights into Estrogen/Estrogen Receptor Effects in the Cardiac and Skeletal Muscle

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Decreases in the levels of the steroid hormone estrogen at menopause are associated with an increased incidence of cardiovascular disease and a loss of skeletal muscle mass and strength. Consequently, it has been generally expected that estrogen may be crucial for the protection against the development of ...

Decreases in the levels of the steroid hormone estrogen at menopause are associated with an increased incidence of cardiovascular disease and a loss of skeletal muscle mass and strength. Consequently, it has been generally expected that estrogen may be crucial for the protection against the development of disease and that it may be implicated in the regulation of striated muscle function. To this extent, estrogen-based hormone therapies appear to result in stronger muscle. Several studies have also investigated the actions of estrogen in the heart indicating direct cardiac estrogenic effects. Notably, it was shown that in the healthy mouse heart estrogen leads to different effects between genetic backgrounds.

These are emerging aspects of a very interesting area with this Research Topic offering a platform for novel discussions and hypotheses. Detailed characterization of the regulation of (patho)physiology by estrogen and its receptors (ER α and β) in cardiac and skeletal muscle, along with elucidation of the underlying mechanisms may lead to the identification of novel therapeutic targets, which may have a wide implication in the development of new and personalized therapies.

This Research Topic aims at novel insights and perspectives in the field of estrogen and muscle. Particularly, it will be appealing to clinicians, translational scientists and basic researchers with an interest in cardiovascular endocrinology and physiology, and skeletal muscle biology and function.

Original research manuscripts and state-of-the-art reviews of recent findings will be considered for the following sub-topics, among others:

Functional consequences of administration or loss of E2 in cardiac and skeletal muscle;

Mechanisms of estrogen deficiency contributing to pathologies of striated muscle;

Cellular effects of E2 on myocyte and non-muscle cells in cardiac and skeletal muscle;

Gene regulation by estrogen in cardiac and skeletal muscle;

Role of estrogen in epigenetic regulation in cardiac and skeletal muscle;

Estrogen signaling in cardiac and skeletal muscle; and

Bioinformatic analysis and in silico modeling of estrogenic effects in cardiac and skeletal muscle.


Keywords: Estrogen, Receptor, Heart, Skeletal Muscle, Steroid


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