Research Topic

Strained Aza-Heterocycles in Synthesis

  • Submission closed.

About this Research Topic

“Strain” in organic molecules is a powerful driving force able to promote reactivity through “strain-release”. This concept of strain is often wrongly associated with the idea of instability and cumbersome synthetic routes to access strained molecules, but kinetic and thermodynamic worlds ignore each other ...

“Strain” in organic molecules is a powerful driving force able to promote reactivity through “strain-release”. This concept of strain is often wrongly associated with the idea of instability and cumbersome synthetic routes to access strained molecules, but kinetic and thermodynamic worlds ignore each other since strained molecules can be perfectly stable while highly reactive in a “designed” reaction. On the other hand, nitrogen heterocycles are ubiquitous and can be found in almost 60% of the 200 top-selling drugs, so that new synthetic tools for their preparation is a hot topic, and source of continuous innovation.

The research topic « strained aza-heterocycles in synthesis » aims at gathering papers reporting the use of three and four-membered aza heterocycles, (ie: aziridines, azetidines, azetidinones) as well as their activated forms (aziridinium and azetidiniums), or their unsaturated forms (azirines and azetines) in synthesis. The inherent strain in these species (whose list is not restricted to cited ones) is the driving force to promote various new synthetic methodologies, such as ring expansions, ring opening, domino processes… that have gained increasing attention over past years, and some have become powerful tools that can be used in total synthesis as elegant key-steps or as innovative tools in diversity-oriented-synthesis.

Papers reporting such methodologies, as well as new optimized synthetic routes to these strained heterocycles, would be welcome, together with papers analyzing fundamental aspects of the mechanism of the highly diverse reactions involved in strain-release.


Keywords: strained aza-heterocycles, synthetic methodologies, reactions mechanisms


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..