About this Research Topic
Understanding the mechanics of biomaterials is essential for improving the prevention, diagnosis, prognosis, and treatment of tissue injuries and diseases. It is also necessary to identify key biomaterial features including extracellular matrix (ECM) parameters (geometry, stiffness, cell adhesion, etc.) for regulating its remodeling process and designing an optimal cellular environment and, thus, engineered tissue. Since the initial call for this Topic, numerical and experimental tools for evaluating trauma/disease, including the ECM and cellular behavior in terms of microstructure and stiffness, have been developed and shown to play important roles. Thus, the focus of this Research Topic will be on applying such tools and engineering principles, together with the current knowledge relating to material science and biology, for better understanding of tissues at different scales as well as engineering biomaterials.
This re-launched Research Topic therefore covers both biological materials, such as tissues, as well as replacement materials ranging from the cellular scale to the tissue and organ scale but, in particular, multidisciplinary applications related to developing models of trauma or disease. Submissions to the Topic utilize computational modeling techniques and/or experimental characterizations of biological and replacement materials that could be used to reveal the structure-function relationship within injured/diseased and non-injured/non-diseased tissues at multiple scales. Submissions also include developing new prevention solutions, treatment methodologies, as well as new biomaterials such as functionally graded materials.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.