GM
giampaolo morciano
University of Bari Aldo Moro
Bari, Italy
About this Research Topic
This Research Topic is closed for submissions.
Background
Intracellular organelles have been traditionally viewed as individual biological entities with static morphology, organization and function. However, it is current opinion in biology that membranes of these organelles are dynamic and engage in structural and functional communications, creating new intracellular compartments with their own pool of proteins; these contact sites are involved in multiple molecular pathways ranging from lipid metabolism, material exchange, response to cellular stress to cell death. Among intracellular organelles, mitochondria play a crucial role in cell bioenergetics and in all those pathways. They are more abundant in cardiomyocytes, constituting 35% of the total cell volume, as the heart is an organ with a high-energy demand. Thus, it is not surprising that their dysfunction leads to cardiovascular diseases and defect in heart development and differentiation.
Following the first volume Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology, this research topic is aimed at providing researchers with an exclusive platform to publish their latest findings in understanding the mechanisms and functions of mitochondrial dynamics, remodeling, and inter-organelle communications (not only those involving mitochondria) in the physiopathology of the heart, in addition to discussing the concerns and advances in the field through reviews, brief research reports and opinion articles.
Subtopics of interest for this second volume include, but are not limited to:
- Mitochondria- and inter-organelle communications-related impairments affecting myocardial bioenergetics
- Calcium (Ca2+) handling and calcium cycling in the heart and link to arrhythmya, ischemia/reperfusion and the failing heart
A full list of accepted article types, including descriptions, can be found at this link.
Keywords: Mitochondria, Cardiovascular Physiopathology, Inter-Organellar Contacts, Cardiomyocytes
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
