Like 0

Spike-timing dependent plasticity

Edited by: Henry Markram, Wulfram Gerstner, Per Jesper Sjöström

Publisher: Frontiers Media SA

ISBN: 978-2-88919-043-0

Product Name: Frontiers Research Topic Ebook

Hebb's postulate provided a crucial framework to understand synaptic alterations underlying learning and memory.

Hebb's theory proposed that neurons that fire together, also wire together, which provided the logical framework for the strengthening of synapses. Weakening of synapses was however addressed by "not being strengthened", and it was only later that the active decrease of synaptic strength was introduced through the discovery of long-term depression caused by low frequency stimulation of the presynaptic neuron. In 1994, it was found that the precise relative timing of pre and postynaptic spikes determined not only the magnitude, but also the direction of synaptic alterations when two neurons are active together. Neurons that fire together may therefore not necessarily wire together if the precise timing of the spikes involved are not tighly correlated. In the subsequent 15 years, Spike Timing Dependent Plasticity (STDP) has been found in multiple brain brain regions and in many different species. The size and shape of the time windows in which positive and negative changes can be made vary for different brain regions, but the core principle of spike timing dependent changes remain. A large number of theoretical studies have also been conducted during this period that explore the computational function of this driving principle and STDP algorithms have become the main learning algorithm when modeling neural networks. This Research Topic will bring together all the key experimental and theoretical research on STDP.

Like 0
Related Content
Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function
Brain derived neurotophic factor (BDNF) and its receptor tropomyosin...
Neural Masses and Fields: Modelling the Dynamics of Brain Activity
Biophysical modelling of brain activity has a long and illustrious...
People also looked at
E-book: Frontiers in Neuroscience
(Vol 4, Issue 1), Theme on Neurodegeneration
Frontiers in Neuroscience with the special theme on Neurodegeneration...
Beyond open access: visions for open evaluation of scientific papers by post-publication peer review
A scientific publication system needs to provide two basic services:...
Interval Timing and Time-Based Decision Making
The perception of time is crucial for everyday activities from the...
The Neocortical column
The columnar organization is currently the most widely held hypothesis...
The Neural Circuit for Spatial Representation
How do we find our way? The discovery of medial entorhinal cortex...

© 2007 - 2015 Frontiers Media S.A. All Rights Reserved