About this Research Topic
The efficient maintenance of genomic stability is central to all life. In order to protect and maintain the genome, cells possess a complex network of surveillance and repair pathways to confront DNA damage directly. Highlighting the importance of these pathways, mutations in proteins involved in DNA repair have been associated with a range of diseases, including neurodegeneration, premature aging and cancer predisposition. Cellular DNA damage is primarily the product of normal cellular metabolism, predominantly from mitochondrial respiration during the generation of ATP. Aberrant repair of DNA lesions can lead to mutation of the genome, which can promote tumorigenesis through the dysregulation of cell growth and death. Due to the rapid growth and unstable genomes of tumor cells, targeting DNA damage and repair pathways has long been an anti-cancer strategy.
The aim of this Research Topic is to feature recent and novel research findings, focusing on mammalian genome stability pathways and/or the links between genome stability and cancer. This focus issue aims to give researchers the opportunity to submit review and original research articles which feature the most recent developments and perspectives in the genome stability field. Recent developments in the genome stability field include the involvement of DNA:RNA hybrids in the repair of DNA double-strand breaks. We aim to include articles identifying new proteins and pathways involved in the maintenance of genome stability and DNA repair, DNA repair proteins that mediate the response to cancer chemotherapy and review articles across the genome stability research area.
The articles that would be suitable for this focus issues include:
• Original Research articles identifying novel DNA repair factors and pathways involved in the sensing, signalling and repair of DNA damage.
• Original Research articles investigating DNA repair factors that are implicated in tumorigenesis.
• Original Research articles investigating DNA repair proteins that mediate the response to cancer therapy and/or could be potential biomarkers for anti-cancer agents.
• Review articles or mini-review articles covering all aspects of DNA repair and genome stability and/or links to cancer.
• Methods articles, including new or updated methods for measuring DNA repair and genome stability.
Dr. Emma Bolderson is a co-founder of Carpe Vitae Pharmaceuticals and is a co-inventor on provisional patent applications filed by Queensland University of Technology. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: DNA Damage, Genome Instability, DNA Repair, Tumorigenesis, Cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.