About this Research Topic
The goal for this research topic focuses on mechanisms and characterization of different TMEs with lymphocyte excluded phenotypes. There have been a few studies examining both physical and soluble mechanisms for lymphocyte exclusion from the TME and we believe a better understanding of the underlying mechanisms of exclusion could elicit targets that could transform excluded tumors to immune hot tumors with the potential to improve patient prognosis and response to therapy. We welcome Original Research, Review and Mini-review articles related to, but not limited to the following topics:
• Characterization of physical and soluble factors leading to lymphocyte exclusion
• Correlation of excluded phenotypes with clinical outcome
• Characterization of lymphocytes in excluded TMEs
• Exclusion of cellular therapies into the TME (e.g. CART)
• Therapeutic interventions to overcome mechanisms of lymphocyte exclusion
Dr. Church is a stockholder and employee of Nanostring Technologies. Dr. Van de Ven receives financial support from Genmab BV. All other Topic Editors declare no conflict of interest in relation to the Research Topic theme.
Keywords: tumor microenvironment, lymphocytes, immune barrier, cold tumors, lymphocyte exclusion
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