Tissue regeneration is a multidisciplinary technology that integrates stem cells, scaffolds and bioactive agents to improve or replace biological tissues. Stem cells, according to their resources, are pluripotent or multipotent seed cells able to specialize in cell-type under different induction conditions. Scaffolds can be metallic, polymeric and inorganic materials. Stem cells and scaffolds can be made into tissue engineered implants for the repair of tissue defects. Bioactive agents can be naturally-derived or synthetic cytokines, growth factors, extracellular vesicles, small-molecules and peptides with one or multiple functions such as osteoinduction, osteoconduction, anti-inflammation, anti-cancer and anti-osteoclast. These bioactive agents are highly important to functionalize the tissue engineered implants with an aim to promote defect healing and/or antagonize the influences of adverse conditions. The methods to integrate bioactive agents into implants include internal incorporation, electrostatic deposition, surface modification and entrapment.
This Research Topic focuses on basic and applied research that adopts advanced controlled release systems of bioactive agents into biomaterials design, to promote the regeneration of tissues, and restore the functions of tissues and/or organs. The topic welcomes, but is not limited to, Original Research, Reviews, and Mini Reviews in the following research areas:
1) Design, development and evaluation of novel bioactive agents for tissue engineering
2) Advanced control release systems of bioactive agents
3) The interaction between regenerative microenvironments and the release of bioactive agents
4) 3D printed functional scaffolds and organelles
5) Advanced systems based on functional biomaterials and stem cells
6) Cells-scaffold interactions for tissue regeneration
Tissue regeneration is a multidisciplinary technology that integrates stem cells, scaffolds and bioactive agents to improve or replace biological tissues. Stem cells, according to their resources, are pluripotent or multipotent seed cells able to specialize in cell-type under different induction conditions. Scaffolds can be metallic, polymeric and inorganic materials. Stem cells and scaffolds can be made into tissue engineered implants for the repair of tissue defects. Bioactive agents can be naturally-derived or synthetic cytokines, growth factors, extracellular vesicles, small-molecules and peptides with one or multiple functions such as osteoinduction, osteoconduction, anti-inflammation, anti-cancer and anti-osteoclast. These bioactive agents are highly important to functionalize the tissue engineered implants with an aim to promote defect healing and/or antagonize the influences of adverse conditions. The methods to integrate bioactive agents into implants include internal incorporation, electrostatic deposition, surface modification and entrapment.
This Research Topic focuses on basic and applied research that adopts advanced controlled release systems of bioactive agents into biomaterials design, to promote the regeneration of tissues, and restore the functions of tissues and/or organs. The topic welcomes, but is not limited to, Original Research, Reviews, and Mini Reviews in the following research areas:
1) Design, development and evaluation of novel bioactive agents for tissue engineering
2) Advanced control release systems of bioactive agents
3) The interaction between regenerative microenvironments and the release of bioactive agents
4) 3D printed functional scaffolds and organelles
5) Advanced systems based on functional biomaterials and stem cells
6) Cells-scaffold interactions for tissue regeneration