About this Research Topic
Site specific and targeted delivery of therapeutic agents to specific organs, tissues and cells for the treatment of diseases is essential to increase drug efficacy and reduce the toxic side effects. Employing specially designed nanoparticles as carriers of these therapeutic agents has proven to be effective for transporting drugs to the target and releasing when needed. Targeting is achieved by binding ligands to the nanoparticle surface to increase their uptake by the cells; enabling the targeting of different cells by changing the ligands used. Triggered release, which allows for drug release only at the target site, is achieved by using functional materials as the carrier particles that respond to changes in the target environment. Spherical nanoparticles are the most widely used nanostructures due to their relatively simple synthesis. However, spherical nanoparticles suffer from low drug loading capacities. Compared to zero dimensional nanoparticles (i.e. spherical nanoparticles), one dimensional nanostructures (i.e. nanorods, nanofibers or nanotubes) have the advantages of high loading capacities and enhanced targeting due to their high surface to volume ratios.
However, compared to spherical nanoparticles, one dimensional nanostructures have been explored less as drug carriers, which can be attributed to their relatively challenging fabrication methods. Longer circulation times, in addition to the alignment or tumbling of one dimensional nanostructures during transport in the body, strongly impact the performance of these nanostructures as drug carriers. Although there are studies modeling the diffusion of these nanostructures in blood vessels, investigations addressing the effect of their shape on the migration and transport mechanisms are limited. Furthermore, the effect of their shape on the uptake efficiency by the cells needs to be further explored. Therefore, the goal of this Research Topic is to cover recent advances in the development of one dimensional nanostructures as drug delivery platforms.
The scope of the Research Topic is one dimensional nanostructures for drug delivery applications. The areas covered within this scope may include:
• Design and synthesis of one dimensional nanostructures
• Drug loading and release kinetics studies
• Targeting and cellular uptake of nanostructures
• Transport of nanostructures in the body
• Advanced characterization and in vivo imaging techniques
• Submissions of Original Research papers, Short Communications and Reviews will be possible.
Drs. Ince, Stella and Colcite hold patents related to nanostructures/ nanomaterials.
Keywords: Drug Delivery Systems, Nanotubes, Nanorods, Nanofibers
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