Research Topic

The Role of Immunity Signaling in Stem Cell Therapy

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About this Research Topic

Stem cell therapy is a promising regenerative strategy that has emerged as an attractive treatment modality for a wide range of degenerative diseases and traumatic injuries. While the functional benefits of stem cell regenerative therapy were initially postulated to be due primarily to the capacity of stem ...

Stem cell therapy is a promising regenerative strategy that has emerged as an attractive treatment modality for a wide range of degenerative diseases and traumatic injuries. While the functional benefits of stem cell regenerative therapy were initially postulated to be due primarily to the capacity of stem cell differentiation at target tissues, it is now increasingly clear that additional mechanisms of action are at play. A major paradigm shift towards immunity signaling has taken place in delineating the reparative mechanisms underlying stem cell therapy. Decisive advancements in this field of research have recently provided convincing evidence that stem cell therapy derives its effectiveness not only from cell replenishment but also, more importantly, from immune responses.

The involvement of immune components in tissue regeneration following stem cell treatment is an intriguing crossover topic that holds great promise for novel therapies. Our immune system provides vital and multilayered defenses against tissue injury by facilitating an inflammatory response that aims to restore homeostasis via the recruitment of immune cells to the site of injury. Thus, one can envision an evolving immune signaling cascade that may complement or even coordinate stem cell therapies to stimulate the functional regrowth of vital tissues. However, the mechanisms and the roles of immunity signaling in stem cell therapy are still far from being fully understood. As such, research explorations, including efforts to elucidate, harness, and integrate this salutary immune response, may expand the possibilities for stem cell therapy to provide functional rejuvenation in various circumstances.

This Research Topic welcomes the critical analysis of immunity signaling in stem cell therapy in the hopes of further advancing the field of stem cell therapy and improving the outcomes of this cutting-edge technology.

The scope of the current Research Topic is to create a collection of articles addressing the mechanisms and the roles of immunity signalling in stem cell therapy, its role to stimulate the functional regrowth of vital tissues. Potential topics should include, but are not limited to:
• Identification of novel signalling molecules including membrane receptors.
• Crosstalk between developmental and immunity signalling pathways
• The application of novel technologies, including imaging and single-cell sequencing approaches, in investigating the signalling underlying stem cell therapy

Brief Reports, Original Research, Mini-Reviews, and Reviews will be accepted.


Keywords: Stem Cell Therapy, Immunity, Cell Signaling


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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