It is well known that the activation of the circulating renin angiotensin system is involved in
cardiovascular pathology including hypertension, heart failure and is responsible for important organic
changes induced by diabetes. Evidence is now available that independently of the classical system, there
are local renin angiotensin systems in different organs including the heart, circulatory vessels, kidney
and probably brain and that components of these local systems participate in important aspects of
physiology and pathology. Of particular interest is the presence of an intracellular component-the so
called intracrine renin angiotensin system, which seems related to regulation of several cellular
functions. A discussion of the different aspects of this important topic is of relevance to cell biology,
endocrinology, physiology and pathology and justify a comprehensive presentation to the scientific
community organized by experts in their respective fields. This is precisely our proposal.
It is well known that the activation of the circulating renin angiotensin system is involved in
cardiovascular pathology including hypertension, heart failure and is responsible for important organic
changes induced by diabetes. Evidence is now available that independently of the classical system, there
are local renin angiotensin systems in different organs including the heart, circulatory vessels, kidney
and probably brain and that components of these local systems participate in important aspects of
physiology and pathology. Of particular interest is the presence of an intracellular component-the so
called intracrine renin angiotensin system, which seems related to regulation of several cellular
functions. A discussion of the different aspects of this important topic is of relevance to cell biology,
endocrinology, physiology and pathology and justify a comprehensive presentation to the scientific
community organized by experts in their respective fields. This is precisely our proposal.
