About this Research Topic
Microbes and humans live in a mutually advantageous symbiotic association, crucial for maintaining intestinal homeostasis.
The human intestinal microbiota, composed by bacteria, viruses, fungi, yeasts, archaea and protozoa, is dynamic and influenced by age, genetics, diet and other environmental factors (e.g. antibiotic intake).
Gut microbiota is strongly influenced by diet, and this process is clearly identifiable when observing the microbial changes due to different diet regimes.
The study of gut microbial modifications in association with changes in diet administration, has made possible to identify a deep relationship between these two factors and the well-being status of the host.
Food-derived molecules have been shown to influence the immune response of the host, through its interaction with the gut microbiota.
Fruit and vegetables are rich in phytochemicals, with demonstrated anti-oxidant and anti-inflammatory activity in different cells, even if their mechanisms of actions have not been completely identified.
Medicine is moving towards personalization, so it has to be done by nutritional regimens that need to become personalized diets for patients. Different kinds of diets have to be suggested as adjuvant therapy for different pathologies.
After birth and likely before, food exposure, nursing and other environmental factors direct microbiota development, which in turn influence the innate and adaptive immunity of the host. Events that change this delicate cascade of events and perturb the correct microbial colonization may result in increased disease susceptibility during life.
It is particularly important to study the role of different food components in shaping the gut microbiota composition and intestinal homeostasis, in order to understand the relationship between environment, genetics and epigenetics.
We welcome contributions on but not limited to:
- original research paper focused on the role of nutraceutic in patients management;
- original research paper explaining the interplay between nutrients and food-derived metabolites and microbial communities resident in the gut;
- original research paper that showed the role of specific foods in the immune response of the host;
- research paper that explain the role of the diet in shaping the intestinal microbiota composition, particularly focused on different developing stage of the host;
- review that underlined how different kinds of diets are able to differently influence the microbial communities of the gut.
Keywords: Food, Inflammation, Microbiota, Nutrients, Immunity
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