About this Research Topic
The defects of periodontal tissues are the result of either disease or trauma. The major challenge in modern dentistry is the recovery of healthy, functional, and esthetically satisfactory periodontal tissue. Periodontium is a complex tissue consisting of several hard and soft tissues; therefore, periodontal regeneration is challenging. Conservative periodontal therapy alone is often insufficient for tissue recovery, and periodontal tissue regeneration is inconceivable without applying different biomaterials. The application of nanotechnologies could be a useful tool for the regeneration of complex periodontal tissue, and attention to this research area has tremendously grown within recent years.
The diversity of biomaterials applied in periodontal regeneration includes, but is not limited to, guided tissue regeneration membranes, tissue grafts, dental implants, and bioactive substances. The modern tissue engineering approaches, based on the combination of stem cells, scaffold, and bioactive proteins, as well as surface bio-modification of dental implants, have intensively developed in recent years.
The application of nanotechnologies might improve all three pillars of tissue regeneration. Nanotopographical modification of scaffold structure or dental implant surfaces would influence the cellular response of stem cells. Altered cell response will affect the processes underlying the resolution of inflammation, angiogenesis, osteogenesis, wound healing. These processes should be coordinated in time to allow the formation of functional periodontal tissue. Such coordination can be achieved by timely delivery of specific growth factors using nanoparticle-based drug delivery systems. Thus, nanotechnologies provide very bright perspectives in dentistry. However, the response of periodontal derived cells to nanostructures, and the clinical effectivity of nanomaterials is not entirely clear. Understanding the mechanisms underlying the periodontal regeneration and effectivity of nanomaterials is necessary for further material development and clinical protocol optimization.
This Research Topic aims to provide an overview and the state of the art progress on nanomaterial application in periodontology. The manuscripts in this Research topic are intended to provide new information about different aspects of nanotechnology-based applications in periodontal regeneration. We expect studies using a variety of approaches, including in vitro studies, pre-clinical animal research, and clinical trials.
Original Research Articles, Reviews, Systematic Reviews, Perspectives, Case Reports, and Opinions on the following subjects can be included:
• Nanotopography and cell response
• Guided tissue regenerative membranes
• Nanoparticle-based drug delivery
• Advances in dental implants
• Nanotechnologies in periodontal regeneration
Prof. Steinberg is the Chief Advisor and Co-Founder of Neo Modulus (Suzhou) Medical Sci-Tech Co., Ltd. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Periodontal Tissue Engineering, Nanomaterials, Guided Tissue Regeneration, Nanoscale Modification of Dental Implant Surface, Nanoparticles
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