Cytokine-ion channel interactions in pulmonary inflammation

91.7K

views

104

authors

16

articles

Editorial

06 November 2018

Editorial: Cytokine-Ion Channel Interactions in Pulmonary Inflammation

István Vadász

and

Rudolf Lucas

2,218 views

5 citations

Editors

2

István Vadász

Universities of Giessen and Marburg Lung Center

Medical College of Georgia, Augusta University

Impact

About

The lower airways represent an integral part of the respiratory system, passing oxygen from the alveolar space into the capillary bed and removing CO2 from the blood. To that purpose, it is crucial that the majority of the 266 million alveoli in an adult human lung remain dry and that the alveolar-capillary barriers are tight. Vectorial sodium transport through the apically expressed epithelial sodium channel (ENaC) and the basolateral sodium-potassium pump (Na+-K+-ATPase) in alveolar epithelial cells is crucial for alveolar liquid clearance. These pathways are moreover either negatively or positively affected by the direction of chloride transport through the cystic fibrosis transmembrane conductance regulator (CFTR). Failure to control lung liquid clearance can lead to the development of pulmonary permeability edema. Inflammatory cytokines and chemokines, induced during bacterial and viral infection, such as TNF, IFN-?, TGF-ß1, IL-1ß, IL-8 and KGF were shown to affect alveolar liquid clearance, since they can alter ion channel and barrier function, through a complex multitude of mechanisms.
This research topic will review recent developments in this field, with relevance to disease states, such as pneumonia, ARDS and ischemia-reperfusion-induced lung injury. A better knowledge of the complex interactions between inflammatory cytokines and ion channels can foster the development of novel therapies towards pulmonary edema.

The lower airways represent an integral part of the respiratory system, passing oxygen from the alveolar space into the capillary bed and removing CO2 from the blood. To that purpose, it is crucial that the majority of the 266 million alveoli in an adult human lung remain dry and that the alveolar-capillary barriers are tight. Vectorial sodium transport through the apically expressed epithelial sodium channel (ENaC) and the basolateral sodium-potassium pump (Na+-K+-ATPase) in alveolar epithelial cells is crucial for alveolar liquid clearance. These pathways are moreover either negatively or positively affected by the direction of chloride transport through the cystic fibrosis transmembrane conductance regulator (CFTR). Failure to control lung liquid clearance can lead to the development of pulmonary permeability edema. Inflammatory cytokines and chemokines, induced during bacterial and viral infection, such as TNF, IFN-?, TGF-ß1, IL-1ß, IL-8 and KGF were shown to affect alveolar liquid clearance, since they can alter ion channel and barrier function, through a complex multitude of mechanisms.
This research topic will review recent developments in this field, with relevance to disease states, such as pneumonia, ARDS and ischemia-reperfusion-induced lung injury. A better knowledge of the complex interactions between inflammatory cytokines and ion channels can foster the development of novel therapies towards pulmonary edema.

Download ebook

Share

Editors

István Vadász

Universities of Giessen and Marburg Lung Center

Medical College of Georgia, Augusta University

Impact

91,659 Total views

65,774 Article views

23,395 Article downloads

2,490 Topic views

Published In

Journal Thumbnail

Frontiers in Immunology

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic