Extracellur vesicles (EVs) are membranous vesicles secreted into the extracellular environment by cells. They widely exist in body fluids including blood, urine, serum and saliva, playing an important role in communication between cells. Containing diverse cellular components such as nucleic acids, proteins and metabolites, EVs reflect the state of their parent cells. Recent studies have demonstrated that EVs play a significant role in tumorigenesis and cancer progression, including immunosuppression, angiogenesis, cell migration, and invasion. These attributes make EVs valuable for noninvasive early cancer diagnosis and therapeutic efficacy evaluation, with circulating EVs emerging as a biomarker for "liquid biopsy" in noninvasive cancer diagnosis. Furthermore, EVs possess unique biological structures, which grant them specific properties such as efficient biocompatibility and high blood-brain barrier penetration. Multiple pathways are being explored to develop EV-based therapeutics.
However, traditional methods for separating and characterizing EVs have notable limitations, including low separation purity, yields, specificity, repeatability, and high cost. Therefore, the development of rapid and effective methods for detecting and analyzing EVs in body fluids is imperative. Point-of-care testing (POCT), particularly biosensor-based detection, has gained significant attention as a promising technology to improve the sensitivity of EV extraction due to its instant analysis, ease of use, high sensitivity, rapid response, specificity, and low sample requirement. The advancement of biosensors has enabled their application in clinical translations. Additionally, EVs loaded with therapeutic molecules, such as miRNAs, face challenges of low efficacy and limited targeting. To address these issues, tailored therapeutic EVs designed through engineering approaches have gained focus in recent years.
This Research Topic focuses on emerging technologies in EVs field for biomedical applications and challenges involved in their clinic translations. The topic welcomes, but is not limited to, Original Research, Reviews, and Prospective in the following research areas:
• Advanced nanosystems for EV detection
• Advanced approaches to EV engineering strategies
• EV cargo loading for disease therapy
• Advanced biomaterial based on EV
• New strategies for improving EV isolation and purification
Extracellur vesicles (EVs) are membranous vesicles secreted into the extracellular environment by cells. They widely exist in body fluids including blood, urine, serum and saliva, playing an important role in communication between cells. Containing diverse cellular components such as nucleic acids, proteins and metabolites, EVs reflect the state of their parent cells. Recent studies have demonstrated that EVs play a significant role in tumorigenesis and cancer progression, including immunosuppression, angiogenesis, cell migration, and invasion. These attributes make EVs valuable for noninvasive early cancer diagnosis and therapeutic efficacy evaluation, with circulating EVs emerging as a biomarker for "liquid biopsy" in noninvasive cancer diagnosis. Furthermore, EVs possess unique biological structures, which grant them specific properties such as efficient biocompatibility and high blood-brain barrier penetration. Multiple pathways are being explored to develop EV-based therapeutics.
However, traditional methods for separating and characterizing EVs have notable limitations, including low separation purity, yields, specificity, repeatability, and high cost. Therefore, the development of rapid and effective methods for detecting and analyzing EVs in body fluids is imperative. Point-of-care testing (POCT), particularly biosensor-based detection, has gained significant attention as a promising technology to improve the sensitivity of EV extraction due to its instant analysis, ease of use, high sensitivity, rapid response, specificity, and low sample requirement. The advancement of biosensors has enabled their application in clinical translations. Additionally, EVs loaded with therapeutic molecules, such as miRNAs, face challenges of low efficacy and limited targeting. To address these issues, tailored therapeutic EVs designed through engineering approaches have gained focus in recent years.
This Research Topic focuses on emerging technologies in EVs field for biomedical applications and challenges involved in their clinic translations. The topic welcomes, but is not limited to, Original Research, Reviews, and Prospective in the following research areas:
• Advanced nanosystems for EV detection
• Advanced approaches to EV engineering strategies
• EV cargo loading for disease therapy
• Advanced biomaterial based on EV
• New strategies for improving EV isolation and purification
