About this Research Topic
Parasites Kinetoplastids cause a number of serious diseases that have contributed to death and health problems in humans. The severity of these infections depends in most cases on the nature of the pathogen, on its different degrees of propagation, and on the expression of the virulence factors involved in the immune evasion mechanisms of the host and on the pathogenesis of infection. These details are determinant in the equilibrium of the pathogen-host interaction and the result of this relation, which can vary from symbiosis, mutualism or parasitism.
The objective of this Research Topic is to evaluate the immunological cellular and humoral mechanisms developed by vertebrate hosts and consequently the escape routes that these pathogenic trypanosomatids developed to deceive and escape from protective imune responses. The current issue highlights the research on subversion and modulation of host defense mechanisms associated with the immunopathogenesis of trypanosomatid infections, providing a broad survey of issues in this field. We welcome researchers to submit reviews, opinions, or original research focusing on antiparasite immunity in humans and in experimental models.
All contributions to this Research Topic must be in line with the scope of the specialty and field to which they are submitted, as defined in their mission statements. Manuscripts discovered during any stage of peer review to be outside of the scope may be transferred to a suitable section or field, or withdrawn from review.
Keywords: Infection, Parasitic Pathogens, Pathogenesis, Virulence Factors, Immune Evasion, Trypanosoma cruzi, Trypanosoma brucei, Leishmania sp, Parasite infection, parasite pathology, Parasite imune evasion, Parasite imune recognition, Immunomodulation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.