About this Research Topic
This Research Topic aims to collect recent advances in the field of metalloenzymes inhibition and activation, taking in consideration enzymes such as carbonic anhydrases, matrix metalloproteinases (MMPs), bacterial metalloenzymes, ADAMs (A Disintegrin-like And Metalloproteinases), ADAMTSs (ADAM with Thrombospondin-like motifs), histone deacetylases (HDACs), angiotensin-converting enzyme (ACE), and HIV-1 integrase, among others. Particularly welcome are studies involving the development of small molecules but also glycoconjugates, as well as protein–protein interaction (PPI) inhibitors. Original papers could report not only the design and synthesis of synthetic or natural-derived enzyme inhibitors and activators but also their biological evaluation and pharmacokinetics. It is highly recommended to focus on advanced design and computational chemistry to identify new active compounds.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Design, synthesis, and optimization of new organic and organometallic drugs
• In silico studies focusing on the development of metalloenzyme inhibitors and activators
• Isolation and identification of metalloenzyme inhibitors or activators from different natural sources and their biological effects
• Novel drug delivery systems
• Application of metalloenzyme modulators to treat complex diseases
Keywords: Drug Discovery, Structure–Activity Relationships, Synthesis, Metalloenzyme Inhibitors, Metalloenzyme Activators
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.