Cytokines, produced by both the innate and adaptive components of the immune system, are critical regulators of immune responses in livestock. These molecules, which include interleukins, chemokines, interferons, lymphokines, tumor necrosis factors, growth factors, and adipokines, can act in an autocrine, paracrine, or endocrine manner. They influence a wide range of physiological and pathophysiological processes, from immune cell differentiation to neurobiology and inflammation. Despite their importance, the specific roles of various cytokines in regulating physiological states and their impact on immune responses under stress or inflammation remain poorly understood. Current research has highlighted the need for a deeper understanding of cytokine responses to infections or stressors and their influence on infection risk and disease progression. Addressing these gaps is crucial for developing effective management strategies and interventions in livestock health.This research topic aims to compile original research and review articles that elucidate the roles of cytokines in the health and disease conditions of livestock. The main objectives include investigating the regulations and functions of cytokines in maintaining homeostasis and during inflammatory conditions, exploring how cytokines modulate the function and biology of specific immune cells in response to stress and inflammation, and characterizing cytokine patterns associated with the functional polarization of innate and adaptive immune cells in livestock species. Additionally, the research will examine pathogen-specific modulation of cytokines, unveil novel functions of cytokines through gene editing techniques, and assess the use of recombinant cytokines and cytokine receptor antagonists as therapeutic agents or vaccine adjuvants.To gather further insights into the complex roles of cytokines in livestock health and disease, we welcome articles addressing, but not limited to, the following themes:- Investigating the regulations and functions of cytokines in maintaining homeostasis and during inflammatory conditions.- Exploring how cytokines modulate the function and biology of specific immune cells in response to stress and inflammation.- Characterization of cytokine patterns associated with the functional polarization of innate (monocytes, macrophages, dendritic cells) and adaptive (T helper cells) immune cells in livestock species.- Examining pathogen-specific modulation of cytokines and their impact on immune system activation.- Unveiling novel functions of cytokines through gene editing techniques.- Understanding the role of interferons in viral diseases affecting livestock.- Assessing the use of recombinant cytokines and cytokine receptor antagonists as therapeutic agents or vaccine adjuvants.- Identifying cytokine-based biomarkers correlated with the severity of inflammatory diseases in livestock.
Cytokines, produced by both the innate and adaptive components of the immune system, are critical regulators of immune responses in livestock. These molecules, which include interleukins, chemokines, interferons, lymphokines, tumor necrosis factors, growth factors, and adipokines, can act in an autocrine, paracrine, or endocrine manner. They influence a wide range of physiological and pathophysiological processes, from immune cell differentiation to neurobiology and inflammation. Despite their importance, the specific roles of various cytokines in regulating physiological states and their impact on immune responses under stress or inflammation remain poorly understood. Current research has highlighted the need for a deeper understanding of cytokine responses to infections or stressors and their influence on infection risk and disease progression. Addressing these gaps is crucial for developing effective management strategies and interventions in livestock health.This research topic aims to compile original research and review articles that elucidate the roles of cytokines in the health and disease conditions of livestock. The main objectives include investigating the regulations and functions of cytokines in maintaining homeostasis and during inflammatory conditions, exploring how cytokines modulate the function and biology of specific immune cells in response to stress and inflammation, and characterizing cytokine patterns associated with the functional polarization of innate and adaptive immune cells in livestock species. Additionally, the research will examine pathogen-specific modulation of cytokines, unveil novel functions of cytokines through gene editing techniques, and assess the use of recombinant cytokines and cytokine receptor antagonists as therapeutic agents or vaccine adjuvants.To gather further insights into the complex roles of cytokines in livestock health and disease, we welcome articles addressing, but not limited to, the following themes:- Investigating the regulations and functions of cytokines in maintaining homeostasis and during inflammatory conditions.- Exploring how cytokines modulate the function and biology of specific immune cells in response to stress and inflammation.- Characterization of cytokine patterns associated with the functional polarization of innate (monocytes, macrophages, dendritic cells) and adaptive (T helper cells) immune cells in livestock species.- Examining pathogen-specific modulation of cytokines and their impact on immune system activation.- Unveiling novel functions of cytokines through gene editing techniques.- Understanding the role of interferons in viral diseases affecting livestock.- Assessing the use of recombinant cytokines and cytokine receptor antagonists as therapeutic agents or vaccine adjuvants.- Identifying cytokine-based biomarkers correlated with the severity of inflammatory diseases in livestock.