Research Topic

Secondary Respiratory Infections in the Context of Acute and Chronic Pulmonary Diseases

About this Research Topic

Secondary respiratory bacterial infections arising from pulmonary insults remain a major clinical issue today. Acute or chronic, sterile or infection-driven, pulmonary inflammation predispose to secondary infections. Secondary bacterial infections often result in lethal synergy with primary infection in the lung or, in the case of sepsis, throughout the body. Different mechanisms are implicated in this enhanced susceptibility including disruption of the lung barrier integrity and impaired host defenses. Today’s treatments of secondary bacterial infections are still not effective enough and antibiotic resistance is a major issue. Hence, there is an urgent need for novel therapies.

The goal of this Research Topic is to highlight our current understanding of the mechanisms leading to secondary bacterial infections in the context of pulmonary injury and to update ongoing and future strategies, including immunotherapy, to overcome altered barrier functions and/or immunosuppression to improve patient outcome. We welcome the submission of Review, Mini-Review and Original Research articles covering, but not limited to, the following topics:

1. Consequences of respiratory viral infections on secondary bacterial infections.
2. Consequences of sepsis on secondary bacterial infections.
3. Consequences of chronic pulmonary illnesses on respiratory bacterial super-infection.


Keywords: Secondary Respiratory Infection, Pulmonary Disease, Lung infection, Super-infection


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Secondary respiratory bacterial infections arising from pulmonary insults remain a major clinical issue today. Acute or chronic, sterile or infection-driven, pulmonary inflammation predispose to secondary infections. Secondary bacterial infections often result in lethal synergy with primary infection in the lung or, in the case of sepsis, throughout the body. Different mechanisms are implicated in this enhanced susceptibility including disruption of the lung barrier integrity and impaired host defenses. Today’s treatments of secondary bacterial infections are still not effective enough and antibiotic resistance is a major issue. Hence, there is an urgent need for novel therapies.

The goal of this Research Topic is to highlight our current understanding of the mechanisms leading to secondary bacterial infections in the context of pulmonary injury and to update ongoing and future strategies, including immunotherapy, to overcome altered barrier functions and/or immunosuppression to improve patient outcome. We welcome the submission of Review, Mini-Review and Original Research articles covering, but not limited to, the following topics:

1. Consequences of respiratory viral infections on secondary bacterial infections.
2. Consequences of sepsis on secondary bacterial infections.
3. Consequences of chronic pulmonary illnesses on respiratory bacterial super-infection.


Keywords: Secondary Respiratory Infection, Pulmonary Disease, Lung infection, Super-infection


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 January 2018 Abstract
29 June 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 January 2018 Abstract
29 June 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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