The PML protein: a tumor suppressor and much more

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University of Ferrara

Pier Paolo Pandolfi

Beth Israel Deaconess Medical Center, Harvard Medical School

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Promyelocytic leukemia (PML) protein is a tumor suppressor implicated in tumorigenesis in different tissues. PML is object of intense research on the basis of this premise.
A large number of alternative spliced transcripts are transcribed from the PML gene, resulting in a variety of PML proteins ranging in molecular weight. The different PML isoforms display a complex intracellular distribution while modulating diverse cellular functions such as transcription, DNA-damage response, sumoylation, cellular senescence, neoangiogenesis, differentiation and apoptosis.
PML exerts this pleiotropic role through its functionally interaction and with a large number of key proteins involved in these physiological process.
In this Research Issue, aimed at a comprehensive coverage of the PML field, we accept review articles, perspectives, research articles, Methods, Hypothesis & Theory covering any of the biological aspects involving this intriguing protein with functions not yet completely resolved.

Promyelocytic leukemia (PML) protein is a tumor suppressor implicated in tumorigenesis in different tissues. PML is object of intense research on the basis of this premise.
A large number of alternative spliced transcripts are transcribed from the PML gene, resulting in a variety of PML proteins ranging in molecular weight. The different PML isoforms display a complex intracellular distribution while modulating diverse cellular functions such as transcription, DNA-damage response, sumoylation, cellular senescence, neoangiogenesis, differentiation and apoptosis.
PML exerts this pleiotropic role through its functionally interaction and with a large number of key proteins involved in these physiological process.
In this Research Issue, aimed at a comprehensive coverage of the PML field, we accept review articles, perspectives, research articles, Methods, Hypothesis & Theory covering any of the biological aspects involving this intriguing protein with functions not yet completely resolved.

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Editors

University of Ferrara

Pier Paolo Pandolfi

Beth Israel Deaconess Medical Center, Harvard Medical School

Impact

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Frontiers in Oncology

Molecular and Cellular Oncology

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Frontiers in Cell and Developmental Biology

Molecular and Cellular Oncology

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