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Thy1/CD90 Surface Glycoprotein: Sensor of Microenvironment?

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Thy1/CD90 is a small and heavily N-glycosylated protein originally described on the cell surface of murine thymocytes. It is today known to be expressed in several other cell type including human fetal thymocytes, hematopoietic stem cells, some subsets of fibroblasts, liver stem/progenitor, neurons, ...

Thy1/CD90 is a small and heavily N-glycosylated protein originally described on the cell surface of murine thymocytes. It is today known to be expressed in several other cell type including human fetal thymocytes, hematopoietic stem cells, some subsets of fibroblasts, liver stem/progenitor, neurons, glioblastoma, mesothelium precursors and mesothelioma cells. In some tissues, Thy-1/CD90 plays a role in different processes such as cell adhesion, interaction with extracellular matrix, migration. However, deep understanding of the control of Thy1/CD90 expression and the signaling that is activated to drive Thy1/CD90 expression; the functional role of its expression; as well as the conservation of some functions across species, which is especially relevant for translational studies is yet to arise.

In this Research Topic, diverse aspects covering missing knowledge such as molecular mechanisms controlling Thy1/CD90 expression and its functional role in physiological and pathological conditions would be further explored.


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