About this Research Topic
In the last twenty years, different discoveries have emphasized the cross-talk between bone and immune cells as well as their common regulatory pathways. Indeed, soluble molecules produced by immune cells modulate the behavior of osteoblasts and osteoclasts. Moreover, osteoclasts, the bone-resorbing cells, originate from the same myeloid precursor cells that differentiated into macrophages and myeloid dendritic cells. Whereas, the bone-forming osteoblastic cells control hematopoietic stem cell niches and thus immune cell ontology. The amplified recognition of the complex relationship between the immune system and bone led to the designation of osteoimmunology field. Potential topics include:
- cytokines released by immune cells affecting bone cell differentiation
- involvement of immune cell in bone diseases
- updates on new pharmacological approaches targeting the cross-talk between bone and immune cells
- bone cell effects on immune cells
- bone marrow niches: Hematopoiesis and bone cell differentiation
Thus, we invite authors to highlight the cross-talk between bone and immune cells, we welcome contributions of different types of articles including original research articles, hypotheses and theory, as well as reviews and mini reviews.
Keywords: Bone, T-cells, B-cells, Bone remodeling, osteoimmunology
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