About this Research Topic
In the last few decades the enormous technological progress, especially omics technologies, expanded the definition of biomarkers from biochemical and clinical by genetic, proteomic, metabolic or microbial markers. Interestingly, some of the biomarker studies additionally provided important insights into the pathophysiology of neurological disorders. In multiple sclerosis TNF-blocking drugs can promote onset or exacerbation of MS and GWAS (genome-wide association studies) data informed about the underlying mechanisms instructing clinical practice. In Parkinson’s disease (PD), evaluation of Lewy pathology provided new pathophysiological insights attributing PD pathology progression to a prion-like process starting in the gastrointestinal tract. However, many other suggested biomarkers remain solely correlative, often lacking a causative link to the underlying disease mechanisms possibly explaining their lack in sensitivity and specificity.
This Research Topic welcomes research articles (including e.g. original research, reviews, perspectives, commentaries, opinions, hypothesis&theory articles) adding new insights into pathomechanisms of neuroimmunological and neurodegenerative disorders from studies on (novel) risk factors and outcome predicting biomarkers. We welcome contributors from diverse disciplines (e.g. neurologists, immunologists, (neuro-) pathologists, neuro-radiologists, biologists) to obtain different perspectives synthesizing a global framework. We hope that this Research Topic will provide a deeper understanding of the pathomechanisms underlying neurological disorders and identify new biomarkers and their pathophysiologic background, thereby facilitating hypothesis-driven refinement of current and novel biomarkers.
Keywords: Biomarker, pathophysiology, neuroimmunology, neurodegeneration, mechanism
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