Research Topic

Viral Evasion Mechanisms of the Host Response

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About this Research Topic

The essential function of the host immune response is to protect the organism against invader pathogens; maintaining tolerance and homeostasis. At the present time, multiple mechanisms have been published that describe how the host sense and respond to virus infections. Viruses are intracellular pathogens ...

The essential function of the host immune response is to protect the organism against invader pathogens; maintaining tolerance and homeostasis. At the present time, multiple mechanisms have been published that describe how the host sense and respond to virus infections. Viruses are intracellular pathogens that have evolved in a number of ways to evade the host detection and to blunt both host innate and adaptive immune responses.

Considering viruses as pathogens with a relatively fast evolutionary rate, the result of host-virus co-evolution depends on the rapid recognition and response by the host as well as on the evasion mechanism by the virus as a continuum fighting for scape/spread and persistence/clearance of virus from the host. In addition, many new interlocutors are continuously described in the field. Viewing how viruses evade the host interactions from different perspectives (transmission, replication, sensing and detecting signals, cellular niche, evasion and effective host response) could help to better understand the mechanistic details of antiviral immunity and viral escape undercover new strategies for antiviral therapeutics.

For this Research Topic, we welcome authors to contribute manuscripts that will illustrate and stimulate the ongoing efforts to understand the complexity of the interplay between virus and host response, related to pathogenesis and evasion mechanisms either at the acute or the chronic phase of infection. Original research, reviews and mini-reviews, perspectives, and hypothesis and theory manuscripts are all welcomed. Although this Research Topic was mainly planned with human viruses in mind, other mammal viruses are also welcome. Particular relevant will be those works that describe the involved mechanism/s at a molecular level.

Topics include but are not limited to the following:
- Viral evasion from host antiviral immune and non-immune defense.
- Viral evasion from host recognition and sensing signals.
- Viral evasion strategies and hijacks pathways.
- Novel regulatory pathways and therapeutic intervention.
- Potential viral mechanisms evasion involved in vaccination.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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